1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. SMAP-2

SMAP-2 (Synonyms: DT-1154)

Cat. No.: HY-120272 Purity: 99.11% ee.: 99.00%
Handling Instructions

SMAP-2 (DT-1154) is an orally active protein phosphatase 2A (PP2A) activator, with anti-cancer activity.

For research use only. We do not sell to patients.

SMAP-2 Chemical Structure

SMAP-2 Chemical Structure

CAS No. : 1809068-70-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 644 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 644 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 890 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SMAP-2 (DT-1154) is an orally active protein phosphatase 2A (PP2A) activator, with anti-cancer activity[1][2].

IC50 & Target

PP2A[1]

In Vitro

SMAP-2 reduces cell viability of pancreatic ductal adenocarcinoma (PDA) cell lines in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SMAP-2 significantly reduces abdominal aortic aneurysms (AAA) incidence and aortic dilation in pro-AAA apolipoprotein E-null (ApoE-/-) mice[2].
SMAP-2 (15 mg/kg; i.g.; daily; 6 days a week; for approximately 14 days) has anti-tumor activity in pancreatic cancer mice model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG mice, with PANC89 cells xenograft[2]
Dosage: 15 mg/kg
Administration: Oral gavage, daily, 6 days a week, for approximately 14 days
Result: Decreased tumor growth and tumor weight.
Molecular Weight

532.57

Formula

C₂₇H₂₇F₃N₂O₄S

CAS No.
SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[[email protected]@H]2[[email protected]@H](O)[[email protected]](N3C4=CC=CC=C4CCC5=CC=CC=C53)CCC2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (563.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8777 mL 9.3884 mL 18.7769 mL
5 mM 0.3755 mL 1.8777 mL 3.7554 mL
10 mM 0.1878 mL 0.9388 mL 1.8777 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 7.5 mg/mL (14.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 7.5 mg/mL (14.08 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.54% ee.: 99.83%

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Keywords:

SMAP-2DT-1154SMAP2SMAP 2DT1154DT 1154Phosphataseproteinphosphatase2AabdominalaorticaneurysmspancreaticductaladenocarcinomaPDAInhibitorinhibitorinhibit

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SMAP-2
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HY-120272
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