1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. SMAP-2

SMAP-2 (Synonyms: DT-1154)

Cat. No.: HY-120272
Handling Instructions

SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers .

For research use only. We do not sell to patients.

SMAP-2 Chemical Structure

SMAP-2 Chemical Structure

CAS No. : 1809068-70-9

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Description

SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers [1].

IC50 & Target

PP2A[1]

Molecular Weight

532.57

Formula

C₂₇H₂₇F₃N₂O₄S

CAS No.

1809068-70-9

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[[email protected]@H]2[[email protected]@H](O)[[email protected]](N3C4=CC=CC=C4CCC5=CC=CC=C53)CCC2)=O

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