1809068-70-9
1809068-70-9
Chemical Structure
SMAP-2
Synonym(s): DT-1154
- CAS No.: 1809068-70-9
- Formula:C27H27F3N2O4S
- Molecular Weight:532.57
IUPAC Name: N-((1S,2S,3R)-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-2-hydroxycyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide
InChIKey: SDVKTCLBCCAFIS-HDYLNDSGSA-N
SMILES: O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[C@@H]2[C@@H](O)[C@H](N3C4=CC=CC=C4CCC5=CC=CC=C53)CCC2)=O
Biological Activity: SMAP-2 (DT-1154) is an orally active protein phosphatase 2A (PP2A) activator, with anti-cancer activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SMAP-2 | 99.53% | SMAP-2 (DT-1154) is an orally active protein phosphatase 2A (PP2A) activator, with anti-cancer activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.76
HY-112929DT-061 -
Similarity Score 0.76
HY-112929B(1S,2S,3R)-DT-061 -
Similarity Score 0.72
HY-124669RTC-30 -
Similarity Score 0.64
HY-123952RTC-5 -
Similarity Score 0.61
HY-131443TRC-766 -
Similarity Score 0.55
HY-156420ATUX-1215 -
Similarity Score 0.54
HY-172143ATUX-8385 -
Similarity Score 0.54
HY-W072940Anticancer agent 7 -
Similarity Score 0.51
HY-147639Cav 2.2/3.2 blocker 1 -
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References
- [1]. Chao Zhang, et al. Abstract 13927: Allosteric Activation of PP2A Inhibits Experimental Abdominal Aortic Aneurysm. 2018. Circulation. 2016;134:A13927.
- [2]. Brittany L Allen-Petersen, et al. Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2019 Jan 1;79(1):209-219. [Content Brief]
