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TRC-766 

Cat. No.: HY-131443 Purity: 98.77%
Handling Instructions

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase.

For research use only. We do not sell to patients.

TRC-766 Chemical Structure

TRC-766 Chemical Structure

CAS No. : 1810734-44-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 254 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase[1].

In Vitro

As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability[1].

Molecular Weight

524.98

Formula

C₂₅H₂₄ClF₃N₂O₃S

CAS No.

1810734-44-1

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(N(CCCN2C3=CC(Cl)=CC=C3CCC4=CC=CC=C42)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (285.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9048 mL 9.5242 mL 19.0483 mL
5 mM 0.3810 mL 1.9048 mL 3.8097 mL
10 mM 0.1905 mL 0.9524 mL 1.9048 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

TRC-766TRC766TRC 766OthersTRC-382negativecontrolPP2AInhibitorinhibitorinhibit

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TRC-766
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