1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. RTC-5

RTC-5 (Synonyms: TRC-382)

Cat. No.: HY-123952 Purity: 98.84%
Handling Instructions

RTC-5 (TRC-382) is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling.

For research use only. We do not sell to patients.

RTC-5 Chemical Structure

RTC-5 Chemical Structure

CAS No. : 1423077-49-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 112 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 112 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

RTC-5 (TRC-382) is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling[1].

IC50 & Target

IC50: EGFR[1]

In Vitro

RTC-5 (0-40 μM; 48 hours) inhibits H1650 lung adenocarcinoma cell growth with an GI50 of 12.6μM[1].
RTC-5 (20-40 μM; 24 hours) negatively regulates PI3K-AKT and RAS-ERK pathways by decreasing phospho-AKT and phospho-ERK levels expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: H1650 lung adenocarcinoma cells
Concentration: 0 μM, 1 μM, 10 μM, 20 μM, 30 μM, 40 μM
Incubation Time: 48 hours
Result: Inhibited H1650 lung adenocarcinoma cell growth.

Western Blot Analysis[1]

Cell Line: H1650 lung adenocarcinoma cells
Concentration: 20 μM, 40 μM
Incubation Time: 24 hours
Result: Decreased p-AKT, p-ERK expression.
Molecular Weight

510.96

Formula

C24H22ClF3N2O3S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 15 mg/mL (29.36 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9571 mL 9.7855 mL 19.5710 mL
5 mM 0.3914 mL 1.9571 mL 3.9142 mL
10 mM 0.1957 mL 0.9786 mL 1.9571 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.5 mg/mL (2.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.5 mg/mL (2.94 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 98.84%

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RTC-5
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