RTC-5 

Cat. No.: HY-123952
Handling Instructions

RTC-5 is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling.

For research use only. We do not sell to patients.

RTC-5 Chemical Structure

RTC-5 Chemical Structure

CAS No. : 1423077-49-9

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Description

RTC-5 is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling[1].

IC50 & Target

IC50: EGFR[1]

In Vitro

RTC-5 (0-40 μM; 48 hours) inhibits H1650 lung adenocarcinoma cell growth with an GI50 of 12.6μM[1].
RTC-5 (20-40 μM; 24 hours) negatively regulates PI3K-AKT and RAS-ERK pathways by decreasing phospho-AKT and phospho-ERK levels expression[1].

Cell Viability Assay[1]

Cell Line: H1650 lung adenocarcinoma cells
Concentration: 0 μM, 1 μM, 10 μM, 20 μM, 30 μM, 40 μM
Incubation Time: 48 hours
Result: Inhibited H1650 lung adenocarcinoma cell growth.

Western Blot Analysis[1]

Cell Line: H1650 lung adenocarcinoma cells
Concentration: 20 μM, 40 μM
Incubation Time: 24 hours
Result: Decreased p-AKT, p-ERK expression.
Molecular Weight

510.96

Formula

C₂₄H₂₂ClF₃N₂O₃S

CAS No.

1423077-49-9

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(NCCCN2C3=CC(Cl)=CC=C3CCC4=CC=CC=C42)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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RTC-5
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