1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. DT-061

DT-061 

Cat. No.: HY-112929 Purity: 99.97%
Handling Instructions

DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.

For research use only. We do not sell to patients.

DT-061 Chemical Structure

DT-061 Chemical Structure

CAS No. : 1809427-19-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 401 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis[1].

IC50 & Target

PP2A[1].

In Vivo

DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient[1].

Animal Model: 6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106)[1].
Dosage: 5 mg/kg.
Administration: Oral gavage for 4 weeks.
Result: Showed activity in inhibiting tumor growth.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (240.14 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9212 mL 9.6058 mL 19.2116 mL
5 mM 0.3842 mL 1.9212 mL 3.8423 mL
10 mM 0.1921 mL 0.9606 mL 1.9212 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.00 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
Molecular Weight

520.52

Formula

C₂₅H₂₃F₃N₂O₅S

CAS No.

1809427-19-7

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[[email protected]]2[[email protected]](O)[[email protected]@H](N3C4=C(C=CC=C4)OC5=CC=CC=C35)CCC2)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
DT-061
Cat. No.:
HY-112929
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DT-061

Cat. No.: HY-112929