Gem-C12
Based on 1 Customer Validation
Gem-C12 is a prodrug of Gemcitabine (HY-17026). Gem-C12 terminates DNA chain elongation, inhibits nucleic acid synthesis and induces Apoptosis. Gem-C12 inhibits the proliferation of glioma cells. Gem-C12 and Honokiol (HY-N0003) exhibit synergistic anti-glioblastoma activity. Gem-C12 can be used in research related to glioblastoma multiforme.
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- 純度: 99.48%
- CAS 番号: 849139-19-1
- 分子式: C21H33F2N3O5
- 分子量:445.50
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Gem-C12 (24 h) inhibits glioblastoma U87 cell viability with an IC50 of 15.74 μM after 24 h of incubation[1].
Free Gem-C12 combined with HNK at a 1:1 mole ratio (24 h) inhibits human glioblastoma U87 cell viability with a Gem-C12 IC50 of 8.75 μM and a synergistic CI of 0.78 after 24 h of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | AUC0-∞ | T1/2 |
|---|---|---|---|---|---|
| Rat[1] | 8.5 μmol/Kg | i.v. | 1250 ± 187 ng/mL | 801 ng·h/mL | 1.14 h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 849139-19-1
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性状 Solid
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分子量 445.50
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分子式 C21H33F2N3O5
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Color White to off-white
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SMILES
O=C1N=C(NC(CCCCCCCCCCC)=O)C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 35 mg/mL (78.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2447 mL | 11.2233 mL | 22.4467 mL | 56.1167 mL |
| 5 mM | 0.4489 mL | 2.2447 mL | 4.4893 mL | 11.2233 mL | |
| 10 mM | 0.2245 mL | 1.1223 mL | 2.2447 mL | 5.6117 mL | |
| 15 mM | 0.1496 mL | 0.7482 mL | 1.4964 mL | 3.7411 mL | |
| 20 mM | 0.1122 mL | 0.5612 mL | 1.1223 mL | 2.8058 mL | |
| 25 mM | 0.0898 mL | 0.4489 mL | 0.8979 mL | 2.2447 mL | |
| 30 mM | 0.0748 mL | 0.3741 mL | 0.7482 mL | 1.8706 mL | |
| 40 mM | 0.0561 mL | 0.2806 mL | 0.5612 mL | 1.4029 mL | |
| 50 mM | 0.0449 mL | 0.2245 mL | 0.4489 mL | 1.1223 mL | |
| 60 mM | 0.0374 mL | 0.1871 mL | 0.3741 mL | 0.9353 mL |
Gem-C12 関連分類
HY-185323 関連分類
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