2. Others Apoptosis Cell Cycle/DNA Damage
  3. Drug Derivative Apoptosis DNA/RNA Synthesis
  4. Gem-C12

Gem-C12 is a prodrug of Gemcitabine (HY-17026). Gem-C12 terminates DNA chain elongation, inhibits nucleic acid synthesis and induces Apoptosis. Gem-C12 inhibits the proliferation of glioma cells. Gem-C12 and Honokiol (HY-N0003) exhibit synergistic anti-glioblastoma activity. Gem-C12 can be used in research related to glioblastoma multiforme.

For research use only. We do not sell to patients.

Gem-C12

Gem-C12 Chemical Structure

CAS No. : 849139-19-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Gem-C12 Related Antibodies

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View All DNA/RNA Synthesis Isoform Specific Products:

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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  • Purity & Documentation

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Description

Gem-C12 is a prodrug of Gemcitabine (HY-17026). Gem-C12 terminates DNA chain elongation, inhibits nucleic acid synthesis and induces Apoptosis. Gem-C12 inhibits the proliferation of glioma cells. Gem-C12 and Honokiol (HY-N0003) exhibit synergistic anti-glioblastoma activity. Gem-C12 can be used in research related to glioblastoma multiforme[1].

In Vitro

Gem-C12 (24 h) inhibits glioblastoma U87 cell viability with an IC50 of 15.74 μM after 24 h of incubation[1].
Free Gem-C12 combined with HNK at a 1:1 mole ratio (24 h) inhibits human glioblastoma U87 cell viability with a Gem-C12 IC50 of 8.75 μM and a synergistic CI of 0.78 after 24 h of incubation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gem-C12 Related Antibodies
Parmacokinetics
Species Dose Route Cmax AUC0-∞ T1/2
Rat[1] 8.5 μmol/Kg i.v. 1250 ± 187 ng/mL 801 ng·h/mL 1.14 h
In Vivo

Hyaluronic acid-grafted micelles encapsulating Gem-C12 and HNK (1:1 mole ratio) (25 μmol/kg; i.v.; every three days; six total doses) achieve an 84.8% tumor inhibitory rate and potent suppression of subcutaneous glioblastoma growth in male Balb/c nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

445.50

Formula

C21H33F2N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(NC(CCCCCCCCCCC)=O)C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (78.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2447 mL 11.2233 mL 22.4467 mL
5 mM 0.4489 mL 2.2447 mL 4.4893 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2447 mL 11.2233 mL 22.4467 mL 56.1167 mL
5 mM 0.4489 mL 2.2447 mL 4.4893 mL 11.2233 mL
10 mM 0.2245 mL 1.1223 mL 2.2447 mL 5.6117 mL
15 mM 0.1496 mL 0.7482 mL 1.4964 mL 3.7411 mL
20 mM 0.1122 mL 0.5612 mL 1.1223 mL 2.8058 mL
25 mM 0.0898 mL 0.4489 mL 0.8979 mL 2.2447 mL
30 mM 0.0748 mL 0.3741 mL 0.7482 mL 1.8706 mL
40 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.4029 mL
50 mM 0.0449 mL 0.2245 mL 0.4489 mL 1.1223 mL
60 mM 0.0374 mL 0.1871 mL 0.3741 mL 0.9353 mL
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Gem-C12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gem-C12849139-19-1Drug DerivativeApoptosisDNA/RNA SynthesisDrug derivativehonokiolnucleic acidblood-brain barrierBalb/c nude miceglioma cellsapoptosisglioblastoma multiformeglioblastomaDNA chain elongationhuman glioblastoma U87 cellsInhibitorinhibitorinhibit

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