Trecovirsen
Based on 1 Customer Validation
Trecovirsen (GEM91) is an antiviral agent targeting HIV gag mRNA, which hybridizes with complementary HIV gag mRNA at the initiation site. Trecovirsen induces a reversible, dose-dependent prolongation of activated partial thromboplastin time via its polyanionic property. Trecovirsen is applicable to research related to HIV infection.
For research use only. We do not sell to patients.
- Purity: 97.98%
- CAS No.: 153021-75-1
- Molecular Weight:7776.30
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
| Species | Dose | Route | Plasma Concentration | AUC0-t | T1/2 | MRT | Tmax |
|---|---|---|---|---|---|---|---|
| Cynomolgus Monkey[2] | 4 mg/kg | i.v. | 41.7 μg/mL | 163 μg·h/mL | 75.4 h | 80 h | 2.13 h |
Chemical Information
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CAS No. 153021-75-1
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Appearance Solid
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Molecular Weight 7776.30
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Color White to off-white
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SMILES
[Trecovirsen]
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Synonyms
GEM91
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 200 mg/mL (25.72 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2242 KB)
References
[1]. Séréni D, et al. Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects. J Clin Pharmacol. 1999;39(1):47-54. [Content Brief]
[2]. Grindel JM, et al. Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion. Antisense Nucleic Acid Drug Dev. 1998;8(1):43-52. [Content Brief]
[3]. Zhang R, et al. Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (GEM 91) developed as a therapeutic agent for human immunodeficiency virus type-1. Biochem Pharmacol. 1995;49(7):929-939. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.1286 mL | 0.6430 mL | 1.2860 mL | 3.2149 mL |
| 5 mM | 0.0257 mL | 0.1286 mL | 0.2572 mL | 0.6430 mL | |
| 10 mM | 0.0129 mL | 0.0643 mL | 0.1286 mL | 0.3215 mL | |
| 15 mM | 0.0086 mL | 0.0429 mL | 0.0857 mL | 0.2143 mL | |
| 20 mM | 0.0064 mL | 0.0321 mL | 0.0643 mL | 0.1607 mL | |
| 25 mM | 0.0051 mL | 0.0257 mL | 0.0514 mL | 0.1286 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Trecovirsen Related Classifications
HY-149906 Related Classifications
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- Trecovirsen
- 153021-75-1
- GEM91
- GEM 91
- GEM-91
- HIV
- mRNA
- acquired immunodeficiency syndrome
- human immunodeficiency virus type 1 infection
- human peripheral blood lymphocytes
- macrophages
- HIV gag mRNA
- activated partial thromboplastin time
- CEM cells
- cynomolgus monkeys
- rhesus monkeys
- Sprague-Dawley rats
- Inhibitor
- inhibitor
- inhibit