2. Anti-infection
  3. HIV
  4. Trecovirsen

Trecovirsen is an antiviral agent targeting HIV gag mRNA, which hybridizes with complementary HIV gag mRNA at the initiation site. Trecovirsen induces a reversible, dose-dependent prolongation of activated partial thromboplastin time via its polyanionic properties. Trecovirsen is applicable to research related to HIV infection.

For research use only. We do not sell to patients.

DNA, d(P-thio)(C-T-C-T-C-G-C-A-C-C-C-A-T-C-T-C-T-C-T-C-C-T-T-C-T)

Trecovirsen Chemical Structure

CAS No. : 153021-75-1

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Based on 1 publication(s) in Google Scholar

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Trecovirsen Related Antibodies

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Description

Trecovirsen is an antiviral agent targeting HIV gag mRNA, which hybridizes with complementary HIV gag mRNA at the initiation site. Trecovirsen induces a reversible, dose-dependent prolongation of activated partial thromboplastin time via its polyanionic properties. Trecovirsen is applicable to research related to HIV infection[1][2][3].

In Vitro

Trecovirsen produces potent, long-lasting inhibitory effects against HIV in cultured HIV-infected cells[1].
Trecovirsen (GEM91) (0.2 μM) potently inhibits HIV-1 replication in multiple in vitro cell models, including acutely and chronically infected CEM cells, human peripheral blood lymphocytes, macrophages, and cells infected with clinical HIV-1 isolates, with an IC50 of 0.2 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trecovirsen Related Antibodies
Parmacokinetics
Species Dose Route Plasma Concentration AUC0-t T1/2 MRT Tmax
Cynomolgus Monkey[2] 4 mg/kg i.v. 41.7 μg/mL 163 μg·h/mL 75.4 h 80 h 2.13 h
In Vivo

Trecovirsen (4 mg/kg; i.v. infusion; over 2 hours) administered via 2-hour intravenous infusion in cynomolgus monkeys results in widespread tissue distribution (with highest accumulation in liver and kidney), a mean plasma elimination half-life of 55.8 hours, a mean blood elimination half-life of 75.4 hours, and excretion of 70% of the dose in urine over 240 hours, with both intact drug and shorter-length metabolites detected in plasma and tissues[2].
Trecovirsen (GEM91) (30 mg/kg; i.v.; single bolus injection) exhibits a short distribution half-life (0.95 hr) and prolonged elimination half-life (47.57 hr) after single i.v. bolus administration at 30 mg/kg in male Sprague-Dawley rats, with wide tissue distribution, preferential retention in kidney, liver, and thyroid, and urinary excretion as the primary elimination pathway[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 100-120 g)[3]
Dosage: 30 mg/kg
Administration: i.v.; single bolus injection
Result: Exhibited a two-compartment plasma disappearance model with half-lives of 0.95 hr (distribution phase) and 47.57 hr (elimination phase); reached a maximum plasma concentration (Cmax) of 418.40 μg/mL, with an area under the curve (AUC) of 1432.51 (μg/mL)·hr, mean residue time (MRT) of 42.59 hr, and clearance (CL) of 20.94 mL/(kg·hr).
Showed intact drug detectable in plasma up to 24 hr post-administration, with mainly intact drug present within 2 hr post-dosing.
Molecular Weight

7776.30

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Trecovirsen]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 200 mg/mL (25.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.1286 mL 0.6430 mL 1.2860 mL
5 mM 0.0257 mL 0.1286 mL 0.2572 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.1286 mL 0.6430 mL 1.2860 mL 3.2149 mL
5 mM 0.0257 mL 0.1286 mL 0.2572 mL 0.6430 mL
10 mM 0.0129 mL 0.0643 mL 0.1286 mL 0.3215 mL
15 mM 0.0086 mL 0.0429 mL 0.0857 mL 0.2143 mL
20 mM 0.0064 mL 0.0321 mL 0.0643 mL 0.1607 mL
25 mM 0.0051 mL 0.0257 mL 0.0514 mL 0.1286 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Trecovirsen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trecovirsen153021-75-1GEM91GEM 91GEM-91HIVHuman immunodeficiency virusacquired immunodeficiency syndromehuman immunodeficiency virus type 1 infectionhuman peripheral blood lymphocytesmacrophagesHIV gag mRNAactivated partial thromboplastin timeCEM cellscynomolgus monkeysrhesus monkeysSprague-Dawley ratsInhibitorinhibitorinhibit

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