CACNB3 - calcium voltage-gated channel auxiliary subunit beta 3 Gene

Also Known as CAB3; CACNLB3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 784

About CACNB3

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:48,814,480-48,828,941 (from NCBI)

This gene has 24 transcripts (splice variants), 280 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 10.3), ovary (RPKM 7.3) and 21 other tissues.

Summary

This gene encodes a regulatory beta subunit of the voltage-dependent Calcium Channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]

CACNB3 Products (4)

mRNA Protein Name
NM_000725.4 NP_000716.2 voltage-dependent L-type calcium channel subunit beta-3 isoform 1
NM_001206915.2 NP_001193844.1 voltage-dependent L-type calcium channel subunit beta-3 isoform 2
NM_001206916.2 NP_001193845.1 voltage-dependent L-type calcium channel subunit beta-3 isoform 3
NM_001206917.2 NP_001193846.1 voltage-dependent L-type calcium channel subunit beta-3 isoform 4

CACNB3 Protein Structure

VGCC_beta4Aa_N

VGCC_beta4Aa_N: Voltage gated calcium channel subunit beta domain 4Aa N terminal (16 - 58)

Guanylate_kin

Guanylate_kin: Guanylate kinase (176 - 354)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit beta-3

  • calcium channel, voltage-dependent, beta 3 subunit

CACNB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CACNB3 P54284 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
32296183
Intra
CACNB3 P54284 CTBP2 Homo sapiens P56545-3
Validated Y2H
32296183
Intra
CACNB3 P54284 CTBP2 Homo sapiens P56545-3
Y2H Array
32296183
Intra
CACNB3 P54284 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
CACNB3 P54284 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
CACNB3 P54284 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
CACNB3 P54284 CIMIP1 Homo sapiens Q9H1P6
Validated Y2H
32296183
Intra
CACNB3 P54284 CIMIP1 Homo sapiens Q9H1P6
Y2H Array
32296183
Intra
CACNB3 P54284 CIMIP1 Homo sapiens Q9H1P6
Y2H Prey Pooling
32296183
Intra
CACNB3 P54284 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra
CACNB3 P54284 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra
CACNB3 P54284 SKIC2 Homo sapiens Q15477
Y2H Prey Pooling
32296183
Intra
CACNB3 P54284 SKIC2 Homo sapiens Q15477
Validated Y2H
32296183
Intra
CACNB3 P54284 SKIC2 Homo sapiens Q15477
Y2H Array
32296183
Intra
CACNB3 P54284 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
CACNB3 P54284 CEP76 Homo sapiens Q8TAP6
Validated Y2H
32296183
Intra
CACNB3 P54284 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
CACNB3 P54284 GEM Homo sapiens P55040
Validated Y2H
32296183
Intra
CACNB3 P54284 CIAPIN1 Homo sapiens Q6FI81
Y2H Prey Pooling
32296183
Intra
CACNB3 P54284 CIAPIN1 Homo sapiens Q6FI81
Y2H Array
32296183
Intra
CACNB3 P54284 CIAPIN1 Homo sapiens Q6FI81
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Arrhythmogenic Right Ventricular Cardiomyopathy

  • Arrhythmogenic Right Ventricular Dysplasia

  • Arvc

  • Arvd

  • Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

  • Arvc Cardiomyopathy

  • Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

  • Arvd/C

  • Right Ventricular Dysplasia, Arrhythmogenic

  • Ventricular Dysplasia, Right, Arrhythmogenic

  • Cardiomyopathy, Ventricular, Right, Arrhythmogenic

  • Dysplasia, Arrhythmogenic Right Ventricular
Distal Hereditary Motor Neuronopathy Type 2

  • Distal Hereditary Motor Neuropathy, Type Ii

  • Distal Hereditary Motor Neuropathy Type 2

  • Distal Hereditary Motor Neuropathy Type Ii

  • Hmn Ii

  • Hmn2

  • Distal Hereditary Motor Neuronopathy, Type Ii

  • Distal Spinal Muscular Atrophy Type 2

  • Dhmn2

  • Dsma2

  • Neuropathy, Motor, Distal, Hereditary, Type Ii

  • Spinal Muscular Atrophy, Jerash Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01807 CACNB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CACNB3 RGD RGD:2248
Felis catus CACNB3 VGNC VGNC:60308
Canis familiaris CACNB3 VGNC VGNC:38646
Bos taurus CACNB3 VGNC VGNC:26685
Mus musculus CACNB3 MGD MGI:103307
Macaca mulatta CACNB3 VGNC VGNC:70511
Others CACNB3 NCBI