2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Glycocyamine

Glycocyamine  (Synonyms: Guanidinoacetic acid)

Cat. No.: HY-W021448 Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

Glycocyamine (Guanidinoacetic acid) is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

For research use only. We do not sell to patients.

Glycocyamine

Glycocyamine Chemical Structure

CAS No. : 352-97-6

Size Price Stock Quantity
Free Sample (0.1 - 0.2 mg)   Apply Now  
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Glycocyamine:

Glycocyamine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Glycocyamine

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms
Human Endogenous Metabolite Microbial Metabolite

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Glycocyamine (Guanidinoacetic acid) is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Glycocyamine promotes myoblast differentiation and skeletal muscle development in mouse C2C12 cells via miRNA-mediated activation of the AKT/mTOR/S6K signalling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycocyamine Related Antibodies
In Vivo

Glycocyamine (0.6-1.2 g/kg; p.o.; ad libitum in feed; grow-out period) supplementation at 0.6 to 1.2 g/kg in broiler diets dose-dependently increases muscle creatine by 14-21%, improves FCR by 4.5-8.8 points, enhances energy metabolism, and reduces dietary arginine requirements[1].
Glycocyamine (0.6-2.4 g/kg; p.o.; ad libitum in feed; breeding period) supplementation at 1.4 g/kg optimises meat-type quail breeder fertility, reducing embryonic mortality and improving egg hatchability, while enhancing progeny performance via increased creatine transfer[1].
Glycocyamine (0.6 g/kg; p.o.; ad libitum in feed; day 11 to 24 of age) supplementation at 0.6 g/kg improves tibia flexibility and energy absorption in male broiler chicks, supporting skeletal development[1].
Glycocyamine (p.o.; ad libitum in feed) supplementation improves growth performance and energy utilisation in turkeys fed all-vegetable diets[1].
Glycocyamine (up to 600-800 mg/kg feed; oral; via diet) increases breast muscle creatine and ATP content and improves growth and performance in chickens[2].
Glycocyamine (0.06-0.78% of diet; p.o.; ad libitum; 9 days) produces consistent improvements in weight gain and feed efficiency in young male New Hampshire × Columbian chicks fed arginine-deficient semi-purified diets, with greater efficacy observed in Arg-deficient versus Arg-adequate diets[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ross 308 (male, female; includes broiler breeder roosters, broiler chicks)[1]
Dosage: 0.6 g/kg; 1.2 g/kg; 1.8 g/kg
Administration: p.o.; ad libitum in feed; grow-out period
Result: Increased muscle creatine by 14% (0.6 g/kg); improved feed conversion ratio by 4.5 points (0.6 g/kg); increased breast muscle phosphocreatine:ATP ratio to 28.4 (vs. control 20.3, 0.6 g/kg); increased breast meat yield (0.6 g/kg); increased muscle creatine by 21% (1.2 g/kg); improved feed conversion ratio by 8.8 points (1.2 g/kg); increased jejunal villus surface area in cool temperatures (1.2 g/kg); improved feed efficiency in low-energy diets (1.2 g/kg); improved antioxidant status and growth performance in low-protein, heat-stressed broilers (0.6 g/kg); reduced arginine requirements by ~142% (based on FCR equivalence, 1.2 g/kg in arginine-deficient diets).
Animal Model: Ross 308 (29-week-old; broiler breeder roosters)[1]
Dosage: 0.6 g/kg; 1.2 g/kg; 1.8 g/kg
Administration: p.o.; ad libitum in feed
Result: Increased fertility rate (all doses); significantly increased semen concentration, total sperm number, and forward motility (1.2 g/kg); increased sperm penetration and improved fertility in aged breeder hens (0.6 and 1.2 g/kg)
Clinical Trial
Molecular Weight

117.11

Formula

C3H7N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CNC(N)=N
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M HCl : 50 mg/mL (426.95 mM; ultrasonic and adjust pH to 1 with HCl)

H2O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Ethanol : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.5390 mL 42.6949 mL 85.3898 mL
5 mM 1.7078 mL 8.5390 mL 17.0780 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.0%

SDS (393 KB)

COA (243 KB) HNMR (223 KB) MS (75 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M HCl 1 mM 8.5390 mL 42.6949 mL 85.3898 mL 213.4745 mL
5 mM 1.7078 mL 8.5390 mL 17.0780 mL 42.6949 mL
10 mM 0.8539 mL 4.2695 mL 8.5390 mL 21.3475 mL
15 mM 0.5693 mL 2.8463 mL 5.6927 mL 14.2316 mL
20 mM 0.4269 mL 2.1347 mL 4.2695 mL 10.6737 mL
25 mM 0.3416 mL 1.7078 mL 3.4156 mL 8.5390 mL
30 mM 0.2846 mL 1.4232 mL 2.8463 mL 7.1158 mL
40 mM 0.2135 mL 1.0674 mL 2.1347 mL 5.3369 mL
50 mM 0.1708 mL 0.8539 mL 1.7078 mL 4.2695 mL
60 mM 0.1423 mL 0.7116 mL 1.4232 mL 3.5579 mL
80 mM 0.1067 mL 0.5337 mL 1.0674 mL 2.6684 mL
100 mM 0.0854 mL 0.4269 mL 0.8539 mL 2.1347 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Glycocyamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycocyamine352-97-6Guanidinoacetic acidEndogenous Metabolitemyogenic differentiation 1 (MyoD)miR-1a-3pmiR-133a-3pAkt/mTOR/S6K signaling pathwaychronic fatigue syndromemouse C2C12 cellsbroiler chicksbroiler chickenspoultry breedersmyogenin (MyoG)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Glycocyamine
Cat. No.:
HY-W021448
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.