BHLHA15 - basic helix-loop-helix family member a15 Gene

Also Known as MIST1; BHLHB8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 168620

About BHLHA15

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:98,211,439-98,215,457 (from NCBI)

This gene has 2 transcripts (splice variants), 174 orthologues and 15 paralogues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; endoplasmic reticulum unfolded protein response; and negative regulation of myotube differentiation. Predicted to act upstream of or within several processes, including glucose homeostasis; intracellular distribution of mitochondria; and mitochondrial calcium ion transmembrane transport. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

BHLHA15 Products (1)

mRNA Protein Name
NM_177455.4 NP_803238.1 class A basic helix-loop-helix protein 15

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BHLHA15 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (76 - 127)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

class A basic helix-loop-helix protein 15

  • MIST-1

BHLHA15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BHLHA15 Q7RTS1 MYOG Homo sapiens P15173
Y2H Array
32296183
Intra
BHLHA15 Q7RTS1 MYOG Homo sapiens P15173
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gastric Fundus Cancer

  • Gastric Fundus Carcinoma

  • Ca Fundus - Stomach

  • Malignant Neoplasm Of Fundus Of Stomach

  • Malignant Tumor Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Carcinoma Of Fundus Of Stomach

  • Malignant Neoplasm Of Gastric Fundus
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01490 BHLHA15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BHLHA15 MGD MGI:891976
Felis catus BHLHA15 VGNC VGNC:80553
Canis familiaris BHLHA15 VGNC VGNC:38444
Bos taurus BHLHA15 VGNC VGNC:26482
Rattus norvegicus BHLHA15 RGD RGD:3091
Macaca mulatta BHLHA15 VGNC VGNC:80800
Others BHLHA15 NCBI