POLR2J - RNA polymerase II subunit J Gene

Also Known as RPB11; RPB11A; RPB11m; hRPB14; POLR2J1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5439

About POLR2J

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,473,128-102,478,922 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 20.7), fat (RPKM 18.2) and 25 other tissues.

Summary

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]

POLR2J Products (3)

mRNA	Protein	Name
NM_001371100.1	NP_001358029.1	DNA-directed RNA polymerase II subunit RPB11-a isoform 2
NM_001393919.1	NP_001380848.1	DNA-directed RNA polymerase II subunit RPB11-a isoform 3
NM_006234.6	NP_006225.1	DNA-directed RNA polymerase II subunit RPB11-a isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables LRR domain binding	IPI IPI: Inferred from physical interaction	10783144	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10783144	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9852112	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II, core complex	IDA IDA: Inferred from direct assay	9852112	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9852112	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR2J Protein Structure

RNA_pol_L_2

0
100
117 a.a.

Protein Preferred Names	Protein Names
DNA-directed RNA polymerase II subunit RPB11-a	DNA-directed RNA polymerase II subunit J-1

POLR2J Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POLR2J	P52435	POLR1C	Homo sapiens	O15160	Anti Tag CoIP	33961781
Intra	POLR2J	P52435	POLR1C	Homo sapiens	O15160	Y2H	21988832
Intra	POLR2J	P52435	POLR1C	Homo sapiens	O15160	Y2H Prey Pooling	32296183
Intra	POLR2J	P52435	POLR1C	Homo sapiens	O15160	Y2H Array	25416956
Intra	POLR2J	P52435	POLR1C	Homo sapiens	O15160	Y2H Array	32296183
Intra	POLR2J	P52435	DRC12	Homo sapiens	Q494R4-2	Y2H Prey Pooling	32296183
Intra	POLR2J	P52435	DRC12	Homo sapiens	Q494R4-2	Validated Y2H	32296183
Intra	POLR2J	P52435	DRC12	Homo sapiens	Q494R4-2	Y2H Array	32296183
Intra	POLR2J	P52435	SNAPC5	Homo sapiens	O75971-2	Y2H Array	32296183
Intra	POLR2J	P52435	SNAPC5	Homo sapiens	O75971-2	Y2H Prey Pooling	32296183
Intra	POLR2J	P52435	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	POLR2J	P52435	MYOG	Homo sapiens	P15173	Y2H Prey Pooling	32296183
Intra	POLR2J	P52435	MYOG	Homo sapiens	P15173	Y2H Array	32296183
Intra	POLR2J	P52435	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 25	Immunodeficiency Due To Defect In Cd3-Zeta IMD25 Immunodeficiency, Type 25

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10851	POLR2J Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10852	POLR2J3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	POLR2J	RGD	RGD:1310198
Mus musculus	POLR2J	MGD	MGI:109582