1. Gene
  2. ISX - intestine specific homeobox Gene

ISX - intestine specific homeobox Gene

Homo sapiens

Also known as Pix-1; RAXLX

Gene ID: 91464 | Gene type: protein coding

About ISX

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,066,158-35,087,387 (from NCBI)

This gene has 2 transcripts (splice variants), 106 orthologues, 50 paralogues and is associated with 51 phenotypes. Biased expression in duodenum (RPKM 20.1), colon (RPKM 15.2) and 1 other tissue.

Summary

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 Amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008]

ISX Products(1)

mRNA Protein Name
NM_001303508.2 NP_001290437.1 intestine-specific homeobox

ISX Protein Structure

Homeobox

Homeobox: Homeobox domain (83 - 139)

  • 0
  • 100
  • 200
  • 245 a.a.
Protein Preferred Names Protein Names

intestine-specific homeobox

RAX-like homeobox

Related Diseases

Diseases Alias
Hypervitaminosis A

Hypervitaminosis A, Susceptibility To

Hyperalimentation Of Vitamin A

Macular Degeneration, Age-Related, 10

ARMD10

Age Related Macular Degeneration 10

Macular Degeneration, Age-Related, Type 10

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris ISX VGNC VGNC:42115
Mus musculus ISX MGD MGI:1918847
Macaca mulatta ISX VGNC VGNC:107796
Bos taurus ISX VGNC VGNC:30305
Felis catus ISX VGNC VGNC:62981
Rattus norvegicus ISX RGD RGD:1592776