2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. ISX-9

ISX-9 (Isoxazole 9) (GMP) is ISX-9 (HY-12323) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. ISX-9 is a small molecule possessing antioxidant, prosurvival, and regenerative properties.

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation.

For research use only. We do not sell to patients.

ISX-9 Chemical Structure

ISX-9 Chemical Structure

CAS No. : 832115-62-5

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ISX-9 Related Antibodies

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Description

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs)[1][2][3]. In Vitro: ISX-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression[1].
Molecular exploration of ISX-9-induced regulation of neurogenesis (via FACS and microarray of SGZ stem and progenitor cells) suggested the involvement of the myocyte-enhancer family of proteins (Mef2)[1]. In Vivo: ISX-9 (20 mg/kg; for 12 days; mice) treatment improves hippocampal function. ISX-9 enhances spatial memory ability in the Morris water maze test. ISX-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2[1].

In Vitro

ISX-9 (20 μM; for 7 days) can induce generated cardiac progenitor cells (CPCs) starting fromhuman-induced pluripotent stem cells (hiPSCs)[1].
ISX-9 (20 μM) induces CPCs to secrete extracellular vesicles (EV)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ISX-9 Related Antibodies

Western Blot Analysis[1]

Cell Line: hiPSCs, CPCs
Concentration: 20 μM
Incubation Time:
Result: Showed EV were enriched in EV-specific markers Tsg101, CD9, Hsp70, and flotillin-1.
In Vivo

CPCISX-9-derived EV reversed cardiac remodeling in infarcted mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID Mice[1]
Dosage: 20 μL (CPCISX-9)
Administration: CPCISX-9 were injected into the myocardium along the border zone.
Result: (EV-CPCISX-9) Promoted CM proliferation and angiogenesis and reversed ventricular remodeling in mice post MI.
Molecular Weight

234.27

Formula

C11H10N2O2S
CAS No.
SMILES

O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ISX-9 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ISX-9 (GMP)832115-62-5Isoxazole 9 (GMP)Calcium ChannelCa2+ channelsCa channelsGMPauxiliary reagentcell therapyantioxidantprosurvivalregenerativeInhibitorinhibitorinhibit

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