832115-62-5
832115-62-5
Chemical Structure
ISX-9
Synonym(s): Isoxazole 9
- CAS No.: 832115-62-5
- Formula:C11H10N2O2S
- Molecular Weight:234.27
IUPAC Name: N-cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide
InChIKey: SYENTKHGMVKGAQ-UHFFFAOYSA-N
SMILES: O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3
Biological Activity: ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs)[1][2][3].
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ISX-9 | 99.76% | ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs). | ||||||||||||||||||||
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ISX-9 (GMP) | ISX-9 (Isoxazole 9) (GMP) is ISX-9 (HY-12323) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. ISX-9 is a small molecule possessing antioxidant, prosurvival, and regenerative properties. | |||||||||||||||||||||
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ISX-9 (Standard) | ≥98% | ISX-9 (Standard) is the analytical standard of ISX-9 (HY-12323). This product is intended for research and analytical applications. ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs). | ||||||||||||||||||||
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References
- [1]. Petrik D, et al. Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule. FASEB J. 2012 Aug;26(8):3148-3162. [Content Brief]
- [2]. Jay W Schneider, et al. Small-molecule activation of neuronal cell fate. Nat Chem Biol. 2008 Jul;4(7):408-10. [Content Brief]
- [3]. Jamie L Russell, et al. Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem Biol. 2012 Jun 15;7(6):1067-76. [Content Brief]
