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PY-60

20 Cited Publications
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Based on 20 publication(s) in Google Scholar

PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 µM. PY-60 directly binds to ANXA2 and antagonizes its normal cellular function of repressing YAP activity.

For research use only. We do not sell to patients.

  • Purity: 99.42%
  • CAS No.: 2765218-56-0
  • Formula: C16H15N3O2S
  • Molecular Weight:313.37
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • PY-60 Chemical Structure
    PY-60 Chemical Structure
  • Experimental Validation Results for PY-60
  • Experimental Validation Results for PY-60
  • Experimental Validation Results for PY-60
  • Experimental Validation Results for PY-60
  • Experimental Validation Results for PY-60
  • Experimental Validation Results for PY-60
CAS No.: 2765218-56-0
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Publications Citing Use of MedChemExpress (MCE) PY-60

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WBRT-PCRIFHistological Imaging/StainingIn Vivo Efficacy StudyBio/Physico-chemical Assay
  • Bio/Physico-chemical Assay
  • WB
  • IF
  • RT-PCR
  • Histological Imaging/Staining
  • In Vivo Efficacy Study

All Annexin A Isoforms

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All YAP Isoforms

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100 mg

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  • PY-60 Chemical Structure
    PY-60 Chemical Structure
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  • 1/16

    PY-60 purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Jul:308:122542. [Abstract]

    Customer Validation
     YAP activity ratio for NIH 3T3 cells treated with inhibitors, one-way ANOVA with multiple comparisons, n=6. The results showed that PY-60 (10 μM; 72 h) significantly increased the YAP activity ratio.

  • 1/16

    PY-60 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Nov 20:225:333-345. [Abstract]

    Customer Validation
     Representative Western blot bands. A total 5.0 μl of PBS, DMSO, U-46619 (0.1 μg/kg) or PY-60 (0.2 mg/kg) were administered via the intracerebroventricular (i.c.v) route at 1.5 h after SAH.

  • 1/16

    PY-60 purchased from MedChemExpress. Usage Cited in: Transl Res. 2024 Jun:268:63-78. [Abstract]

    Customer Validation
     Confocal images of YAP after different treatments for 24 h in H357 Cis R cells, Scale bar = 10 μM. Blue signals indicate cell nuclei stained by DAPI and red indicates the YAP expression. Immunofluorescence was performed in cells from different treatment groups (2.5 μM cisplatin, 10 μM PY-60, 2.5 μM cisplatin + 5 μM PL, 2.5 μM cisplatin + 5 μM smart PL-NPs, 10 μM PY-60 + 2.5 μM cisplatin + 5 μM PL, and 10 μM PY-60 + 2.5 μM cisplatin + 5 μM smart PL-NPs) for 24 h. The primary antibody used was rabbit monoclonal anti-YAP.

  • 1/16

    PY-60 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2024 Aug;57(8):e13640. [Abstract]

    Customer Validation
     Relative mRNA expression levels of M1/M2-associated genes after DMSO, GsMTx4, GsMTx4+PY-60 (10 μM; 12 h) treatment when cultured on stiff substrates (*P<0.05, **P<0.01).

  • 1/16

    PY-60 purchased from MedChemExpress. Usage Cited in: J Bone Miner Metab. 2022 Nov;40(6):890-899. [Abstract]

    Customer Validation
     PY-60 (10 μM, applied topically to the skin on the back of mice for 10 consecutive days).
    IHC analysis was done to detect changes in YAP, Ki67, MMP2, MMP9, MMP14 and cleaved caspase three expressions in indicated groups. **P < 0.01

  • 1/16

    PY-60 purchased from MedChemExpress. Usage Cited in: J Bone Miner Metab. 2022 Nov;40(6):890-899. [Abstract]

    Customer Validation
     Cells transfected with pcDNA3.1 or pcDNA3.1/LINC01089 were injected into mice, and 10 µM PY-60 was applied topically to the dorsal skin of mice over the course of 10 days. Tumor volume was measured in each indicated group every 3 days from day 7, and after all mice were sacrificed at day 28, tumor weight was examined.

  • PY-60