M2WJ332 

M2WJ332 is an inhibitor of the M2 proton channel of the influenza A virus M2^S31N mutant M2. M2WJ332 potently inhibits the influenza A virus A/M2-S31N proton channel in Xenopus laevis oocytes, with an IC₅₀ of 16 μM. M2WJ332 completely inhibits plaque formation by the influenza A virus carrying the M2^S31N mutant. M2WJ332 is applicable to research related to influenza A virus infection^[1][2].

M2WJ332 (Compound 11) (100 μM; 2 min) potently inhibits the activity of the AM2-S31N proton channel in Xenopus laevis oocytes, while exerts extremely weak inhibitory effect on the activity of AM2-WT^[1].
M2WJ332 potently inhibits the replication of AM2-S31N-containing influenza A virus A/California/07/2009 (H1N1) in MDCK cells expressing ST6Gal I, with an EC₅₀ of 0.3 μM^[1].
M2WJ332 (48 h) exhibits cytotoxicity against MDCK cells with a CC₅₀ of 100 μM, and shows a CC₅₀ of 177.5 μM against A549 cells^[1].
M2WJ332 potently inhibits the replication of amantadine (HY-B0402)-resistant influenza A virus strain A/WSN/33 in MDCK cells, with an EC₅₀ of 153 nM, and completely suppresses plaque formation at 10 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

314.45

C₁₈H₂₂N₂OS

1421958-72-6

N=1OC(=CC1CNC23CC4CC(CC(C4)C2)C3)C=5SC=CC5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang Y, et al. In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses. J Med Chem. 2018;61(3):1074-1085.  [Content Brief]

  [2]. Wang J, et al. Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus. Proc Natl Acad Sci U S A. 2013;110(4):1315-1320.  [Content Brief]