M2WJ332
M2WJ332 is an inhibitor of the M2 proton channel of the influenza A virus M2S31N mutant M2. M2WJ332 potently inhibits the influenza A virus A/M2-S31N proton channel in Xenopus laevis oocytes, with an IC50 of 16 μM. M2WJ332 completely inhibits plaque formation by the influenza A virus carrying the M2S31N mutant. M2WJ332 is applicable to research related to influenza A virus infection.
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- CAS. Nr.: 1421958-72-6
- Formel: C18H22N2OS
- Molecular Weight:314.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
177.5 μM
Compound: 11; abstract cpd 1
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Cytotoxicity against human A549 cells after 48 hrs by neutral red assay
Cytotoxicity against human A549 cells after 48 hrs by neutral red assay
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[PMID: 29341607] |
| MDCK | CC50 |
100 μM
Compound: 11; abstract cpd 1
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Cytotoxicity against MDCK cells after 48 hrs by neutral red assay
Cytotoxicity against MDCK cells after 48 hrs by neutral red assay
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[PMID: 29341607] |
| MDCK | CC50 |
100 μM
Compound: 5
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Cytotoxicity against MDCK cells after 48 hrs by neutral red uptake assay
Cytotoxicity against MDCK cells after 48 hrs by neutral red uptake assay
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[PMID: 30429954] |
In Vitro
M2WJ332 (Compound 11) (100 μM; 2 min) potently inhibits the activity of the AM2-S31N proton channel in Xenopus laevis oocytes, while exerts extremely weak inhibitory effect on the activity of AM2-WT[1].
M2WJ332 potently inhibits the replication of AM2-S31N-containing influenza A virus A/California/07/2009 (H1N1) in MDCK cells expressing ST6Gal I, with an EC50 of 0.3 μM[1].
M2WJ332 (48 h) exhibits cytotoxicity against MDCK cells with a CC50 of 100 μM, and shows a CC50 of 177.5 μM against A549 cells[1].
M2WJ332 potently inhibits the replication of amantadine (HY-B0402)-resistant influenza A virus strain A/WSN/33 in MDCK cells, with an EC50 of 153 nM, and completely suppresses plaque formation at 10 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1421958-72-6
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Molecular Weight 314.45
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Formel C18H22N2OS
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SMILES
N=1OC(=CC1CNC23CC4CC(CC(C4)C2)C3)C=5SC=CC5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Wang Y, et al. In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses. J Med Chem. 2018;61(3):1074-1085. [Content Brief]
[2]. Wang J, et al. Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus. Proc Natl Acad Sci U S A. 2013;110(4):1315-1320. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
M2WJ332 Related Classifications
HY-117503 Related Classifications
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