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ISX-1 is an isoxazole. ISX-1 has anti-adipogenic and pro-osteogenic activities. ISX-1 can be used for the research of osteopenia and osteoporosis.

For research use only. We do not sell to patients.

ISX-1 Chemical Structure

ISX-1 Chemical Structure

CAS No. : 909207-35-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1041 In-stock
Solution
10 mM * 1 mL in DMSO USD 1041 In-stock
Solid
1 mg USD 313 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

ISX-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ISX-1 is an isoxazole. ISX-1 has anti-adipogenic and pro-osteogenic activities. ISX-1 can be used for the research of osteopenia and osteoporosis[1].

IC50 & Target

IC50: 1.9 μM (lipid droplet formation); EC50: 1.2 μM (induce ALP)[1]
In Vitro

ISX-1 dose-dependently inhibits the accumulation of intracellular lipid droplets and stimulated ALP activity[1].
ISX-1 can form lipid droplet with an IC50 value of 1.9 μM and also can induce ALP with an EC50 value of 1.2 μM[1].
ISX-1 (0, 1.3, 6.5 and 33 μM; 3 days) inhibited the mRNA induction of PPARγ and FABP4 genes under the adipogenic differentiation of hBMSCs[1].
ISX-1 (0, 1.3, 6.5 and 33 μM) promotes TCF/LEF-mediated gene transcription[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ISX-1 Related Antibodies

RT-PCR[1]

Cell Line: Human bone marrow mesenchymal stem cells (hBMSCs)
Concentration: 0, 1.3, 6.5 and 33 μM
Incubation Time: 3 days
Result: Inhibited the mRNA induction of PPARγ and FABP4 genes under the adipogenic differentiation of hBMSCs and showed no effect on C/EBPα expression.

Western Blot Analysis[1]

Cell Line: HEK 293 cells
Concentration: 6.5 and 33 μM
Incubation Time: 6.5 and 33 μM
Result: Increased both the amount of activated and total β-catenin.
Molecular Weight

302.35

Formula

C14H14N4O2S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(NCCCN1C=CN=C1)C2=NOC(C3=CC=CS3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (165.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3074 mL 16.5371 mL 33.0742 mL
5 mM 0.6615 mL 3.3074 mL 6.6149 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3074 mL 16.5371 mL 33.0743 mL 82.6856 mL
5 mM 0.6615 mL 3.3074 mL 6.6149 mL 16.5371 mL
10 mM 0.3307 mL 1.6537 mL 3.3074 mL 8.2686 mL
15 mM 0.2205 mL 1.1025 mL 2.2050 mL 5.5124 mL
20 mM 0.1654 mL 0.8269 mL 1.6537 mL 4.1343 mL
25 mM 0.1323 mL 0.6615 mL 1.3230 mL 3.3074 mL
30 mM 0.1102 mL 0.5512 mL 1.1025 mL 2.7562 mL
40 mM 0.0827 mL 0.4134 mL 0.8269 mL 2.0671 mL
50 mM 0.0661 mL 0.3307 mL 0.6615 mL 1.6537 mL
60 mM 0.0551 mL 0.2756 mL 0.5512 mL 1.3781 mL
80 mM 0.0413 mL 0.2067 mL 0.4134 mL 1.0336 mL
100 mM 0.0331 mL 0.1654 mL 0.3307 mL 0.8269 mL
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ISX-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ISX-1909207-35-8ISX1ISX 1Othersoncostatin M (OSM)human bone marrow mesenchymal stem cells (hBMSCs)isoxazoleanti-adipogenicpro-osteogenicInhibitorinhibitorinhibit

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