ZFAND2A - zinc finger AN1-type containing 2A Gene

Also Known as AIRAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90637

About ZFAND2A

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:1,148,850-1,160,196 (from NCBI)

This gene has 7 transcripts (splice variants), 123 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 5.6), liver (RPKM 4.6) and 25 other tissues.

Summary

Predicted to enable zinc ion binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein targeting to ER. Predicted to act upstream of or within cellular response to arsenic-containing substance and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of Proteasome complex. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

ZFAND2A Products (3)

mRNA Protein Name
NM_001365381.2 NP_001352310.1 AN1-type zinc finger protein 2A isoform 2
NM_001365383.1 NP_001352312.1 AN1-type zinc finger protein 2A isoform 3
NM_182491.4 NP_872297.2 AN1-type zinc finger protein 2A isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFAND2A Protein Structure

zf-AN1

zf-AN1: AN1-like Zinc finger (10 - 50)

zf-AN1

zf-AN1: AN1-like Zinc finger (100 - 136)

  • 0
  • 100
  • 145 a.a.
Protein Preferred Names Protein Names

AN1-type zinc finger protein 2A

  • arsenite inducible RNA associated protein

ZFAND2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZFAND2A Q8N6M9 PLEKHB2 Homo sapiens Q96CS7
Y2H Prey Pooling
32296183
Intra
ZFAND2A Q8N6M9 PLEKHB2 Homo sapiens Q96CS7
Validated Y2H
32296183
Intra
ZFAND2A Q8N6M9 PLEKHB2 Homo sapiens Q96CS7
Y2H Array
32296183
Intra
ZFAND2A Q8N6M9 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
Intra
ZFAND2A Q8N6M9 RNF216 Homo sapiens Q9NWF9
Validated Y2H
32296183
Intra
ZFAND2A Q8N6M9 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
Intra
ZFAND2A Q8N6M9 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
ZFAND2A Q8N6M9 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
ZFAND2A Q8N6M9 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra
ZFAND2A Q8N6M9 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra
ZFAND2A Q8N6M9 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
ZFAND2A Q8N6M9 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
ZFAND2A Q8N6M9 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16029 ZFAND2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZFAND2A MGD MGI:2140729
Canis familiaris ZFAND2A VGNC VGNC:48600
Rattus norvegicus ZFAND2A RGD RGD:1310991
Bos taurus ZFAND2A VGNC VGNC:37149
Others ZFAND2A NCBI