ZFAND2B - zinc finger AN1-type containing 2B Gene
Also Known as AIRAPL
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 130617
Summary
This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Ubiquitous expression in thyroid (RPKM 23.0), duodenum (RPKM 18.1) and 25 other tissues.
ZFAND2B Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001270998.2 | NP_001257927.1 | AN1-type zinc finger protein 2B isoform 1 |
| NM_001270999.2 | NP_001257928.1 | AN1-type zinc finger protein 2B isoform 2 |
| NM_001437629.1 | NP_001424558.1 | AN1-type zinc finger protein 2B isoform 1 |
| NM_001437630.1 | NP_001424559.1 | AN1-type zinc finger protein 2B isoform 3 |
| NM_001437631.1 | NP_001424560.1 | AN1-type zinc finger protein 2B isoform 3 |
| NM_138802.3 | NP_620157.1 | AN1-type zinc finger protein 2B isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables K48-linked polyubiquitin modification-dependent protein binding |
IDA
IDA: Inferred from direct assay
|
26876100 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within SRP-dependent cotranslational protein targeting to membrane, translocation |
IMP
IMP: Inferred from mutant phenotype
|
24160817 | GOA |
| involved in proteasome-mediated ubiquitin-dependent protein catabolic process |
IMP
IMP: Inferred from mutant phenotype
|
26692333 | GOA |
| involved in protein targeting to ER |
IMP
IMP: Inferred from mutant phenotype
|
26692333 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of proteasome complex |
IDA
IDA: Inferred from direct assay
|
26876100 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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ZFAND2B Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ZFAND2B | Q8WV99 | UBQLN1 | Homo sapiens | Q9UMX0-2 | 25416956 | |
|
Intra
|
ZFAND2B | Q8WV99 | TARDBP | Homo sapiens | G3V162 | 25416956 | |
|
Intra
|
ZFAND2B | Q8WV99 | ASB7 | Homo sapiens | Q9H672-2 | 32296183 | |
|
Intra
|
ZFAND2B | Q8WV99 | ASB7 | Homo sapiens | Q9H672-2 | 32296183 | |
|
Intra
|
ZFAND2B | Q8WV99 | ASB7 | Homo sapiens | Q9H672-2 | 32296183 | |
|
Intra
|
ZFAND2B | Q8WV99 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
ZFAND2B | Q8WV99 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
ZFAND2B | Q8WV99 | DAZAP2 | Homo sapiens | Q15038 | 25416956 | |
|
Intra
|
ZFAND2B | Q8WV99 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
ZFAND2B | Q8WV99 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
ZFAND2B | Q8WV99 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction