TLE1 - TLE family member 1, transcriptional corepressor Gene

Also Known as ESG; ESG1; GRG1; TLE-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7088

About TLE1

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:81,583,683-81,689,547 (from NCBI)

This gene has 7 transcripts (splice variants), 262 orthologues and 6 paralogues. Ubiquitous expression in fat (RPKM 15.1), endometrium (RPKM 10.2) and 25 other tissues.

Summary

Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]

TLE1 Products (3)

mRNA	Protein	Name
NM_001303103.2	NP_001290032.1	transducin-like enhancer protein 1 isoform 1
NM_001303104.2	NP_001290033.1	transducin-like enhancer protein 1 isoform 3
NM_005077.5	NP_005068.2	transducin-like enhancer protein 1 isoform 2

TLE1 Protein Structure

TLE_N

WD40

0
200
400
600
770 a.a.

Protein Preferred Names	Protein Names
transducin-like enhancer protein 1	enhancer of split groucho-like protein 1

TLE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TLE1	Q04724	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	17680780
Intra	TLE1	Q04724	H4C16	Homo sapiens	P62805	Far-WB	24596249
Intra	TLE1	Q04724	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	TLE1	Q04724	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	TLE1	Q04724	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	TLE1	Q04724	SYT-SSX2	Homo sapiens	A4PIW0	Anti Bait CoIP	22439931
Intra	TLE1	Q04724	SYT-SSX2	Homo sapiens	A4PIW0	Anti Tag CoIP	22439931
Intra	TLE1	Q04724	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	TLE1	Q04724	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	TLE1	Q04724	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	TLE1	Q04724	DAZAP2	Homo sapiens	Q15038	Y2H Array	20211142
Intra	TLE1	Q04724	TLE1	Homo sapiens	Q04724	X-Ray Diffraction	24596249
Intra	TLE1	Q04724	RUNX1	Homo sapiens	Q01196-1	Beta Galactosidase	9751710
Intra	TLE1	Q04724	TLE1	Homo sapiens	Q04724	SAXS	24596249
Intra	TLE1	Q04724	RUNX1	Homo sapiens	Q01196-1	Pull Down	9751710
Intra	TLE1	Q04724	RUNX3	Homo sapiens	Q13761	Beta Galactosidase	9751710
Intra	TLE1	Q04724	TLE1	Homo sapiens	Q04724	GMS	24596249
Intra	TLE1	Q04724	FOXG1	Homo sapiens	P55316	Anti Bait CoIP	24356439
Intra	TLE1	Q04724	NOD2	Homo sapiens	Q9HC29	Anti Bait CoIP	21699783
Intra	TLE1	Q04724	NOD2	Homo sapiens	Q9HC29	Y2H	21699783
Intra	TLE1	Q04724	HES6	Homo sapiens	Q96HZ4	Y2H Array	20211142

Cross: Cross-species interaction Intra: Intraspecies interaction

TLE1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82546	TLE1 Antibody (YA2291)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Glomus Tumor	Glomus Neoplasm Glomus Tumour
Thymus Sarcomatoid Carcinoma	Thymic Carcinosarcoma Thymic Sarcomatoid Carcinoma
Monophasic Synovial Sarcoma	Monophasic Sarcoma Of Synovium
Biphasic Synovial Sarcoma	Synovial Sarcoma, Biphasic Biphasic Sarcoma Of Synovium
Malignant Glandular Tumor Of Peripheral Nerve Sheath	Glandular Mpnst Glandular Malignant Peripheral Nerve Sheath Tumor
Tibial Adamantinoma	Tibial Adamantinoma Morphology
Adamantinoma Of Long Bones	Long Bone Adamantinoma
Spindle Cell Synovial Sarcoma	Synovial Sarcoma With Spindle Cell Components Synovial Sarcoma, Monophasic Fibrous Synovial Sarcoma, Spindle Cell
Synovium Cancer	Malignant Tumor Of Synovium Synovial Neoplasm
Cellular Neurofibroma
Cellular Schwannoma	Cellular Neurinoma
Kidney Sarcoma	Renal Sarcoma Sarcoma Of Kidney
Malignant Triton Tumor	Malignant Peripheral Nerve Sheath Neoplasm With Rhabdomyosarcoma Malignant Triton Tumour Mpnst With Rhabdomyoblastic Differentiation Mpnst With Rhabdomyosarcoma Mpnst With Rhabdomyosarcomatous Differentiation Mtt Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous Differenciation Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation
Conventional Leiomyosarcoma
Spindle Cell Thymoma	Medullary Thymoma Thymoma, Medullary Thymoma, Type A
Synovium Neoplasm	Synovial Neoplasm Tumor Of Synovium
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Epithelioid Malignant Peripheral Nerve Sheath Tumor	Epithelioid Mpnst Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath
Kidney Clear Cell Sarcoma	Clear Cell Sarcoma Of Kidney Childhood Kidney Clear Cell Sarcoma Renal Clear Cell Sarcoma Ccsk Clear Cell Sarcoma Of The Kidney
Subungual Glomus Tumor	Subungual Glomus Tumour
Spindle Cell Sarcoma	Sarcoma Sarcoma Spindle Cell Sarcoma, Spindle Cell Sarcoma - Category
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Sarcomatoid Mesothelioma	Malignant Fibrous Mesothelioma Spindled Mesothelioma
Malignant Spindle Cell Melanoma	Spindle Cell Melanoma Desmoplastic Melanoma Spindle Cell Malignant Melanoma Spitzoid Malignant Melanoma
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS21443	Tle1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14563	TLE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10488	cycFWRPW	Activator	/	Unkown
HY-RS27961	Tle1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TLE1	VGNC	VGNC:66208
Mus musculus	TLE1	MGD	MGI:104636
Canis familiaris	TLE1	VGNC	VGNC:47396
Macaca mulatta	TLE1	VGNC	VGNC:78364
Rattus norvegicus	TLE1	RGD	RGD:1309237
Others	TLE1	NCBI