HES6 - hes family bHLH transcription factor 6 Gene

Also Known as HES-6; bHLHb41; bHLHc23; C-HAIRY1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55502

About HES6

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:238,238,267-238,240,038 (from NCBI)

This gene has 9 transcripts (splice variants), 260 orthologues and 12 paralogues. Biased expression in brain (RPKM 23.5), colon (RPKM 8.2) and 12 other tissues.

Summary

This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with Other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

HES6 Products (3)

mRNA Protein Name
NM_001142853.3 NP_001136325.1 transcription cofactor HES-6 isoform b
NM_001282434.2 NP_001269363.1 transcription cofactor HES-6 isoform c
NM_018645.6 NP_061115.2 transcription cofactor HES-6 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HES6 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (26 - 73)

Hairy_orange

Hairy_orange: Hairy Orange (94 - 134)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

transcription cofactor HES-6

  • class B basic helix-loop-helix protein 41

HES6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HES6 Q96HZ4 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra
HES6 Q96HZ4 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra
HES6 Q96HZ4 TLE1 Homo sapiens Q04724
Anti Tag CoIP
33961781
Intra
HES6 Q96HZ4 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
HES6 Q96HZ4 RAB2A Homo sapiens P61019
Y2H Array
32296183
Intra
HES6 Q96HZ4 RAB2A Homo sapiens P61019
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Brain Cancer

  • Adult Brain Tumor

  • Malignant Neoplasm Of Brain

  • Brain Neoplasms

  • Brain Neoplasm

  • Neoplasm Of Brain

  • Primary Malignant Neoplasm Of Brain

  • Brain Tumors

  • Adult Malignant Brain Neoplasm

  • Brain Neoplasm, Adult

  • Bt - Brain Tumour

  • Malignant Brain Tumour

  • Malignant Primary Brain Neoplasm

  • Malignant Primary Brain Tumor

  • Malignant Tumor Of Adult Brain

  • Malignant Tumor Of Brain

  • Primary Brain Neoplasm

  • Primary Brain Tumor

  • Tumor Of The Brain

  • Brain Tumor, Adult

  • Brain Tumor Primary

  • Malignant Primary Brain Tumors

  • Primary Brain Tumors

  • Cancer, Brain

  • Brain Tumor, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10365 VPM-p15 Agonist 98.25% Unkown
HY-RS06139 HES6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20287 Hes6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26795 Hes6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HES6 VGNC VGNC:99366
Felis catus HES6 VGNC VGNC:80228
Canis familiaris HES6 VGNC VGNC:59081
Rattus norvegicus HES6 RGD RGD:1312047
Bos taurus HES6 VGNC VGNC:29823
Mus musculus HES6 MGD MGI:1859852