UBXN2A - UBX domain protein 2A Gene

Also Known as UBXD4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 165324

About UBXN2A

This gene has 4 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 3.2), esophagus (RPKM 2.9) and 25 other tissues.

Summary

Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; regulation of gene expression; and regulation of protein metabolic process. Predicted to be located in cis-Golgi network and endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

UBXN2A Products (1)

mRNA Protein Name
NM_181713.4 NP_859064.2 UBX domain-containing protein 2A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21900206 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of ERAD pathway IMP
IMP: Inferred from mutant phenotype
26265139 GOA
involved in negative regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
26634371 GOA
involved in positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
37037900 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24625977 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24625977 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBXN2A Protein Structure

SEP

SEP: SEP domain (65 - 138)

UBX

UBX: UBX domain (172 - 246)

  • 0
  • 100
  • 200
  • 259 a.a.
Protein Preferred Names Protein Names

UBX domain-containing protein 2A

  • UBX domain containing 4

UBXN2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBXN2A P68543 UBXN6 Homo sapiens Q9BZV1
Validated Y2H
32296183
Intra
UBXN2A P68543 VCP Homo sapiens P55072
Y2H Prey Pooling
32296183
Intra
UBXN2A P68543 VCP Homo sapiens P55072
Validated Y2H
32814053
Intra
UBXN2A P68543 VCP Homo sapiens P55072
Y2H Pooling
32814053
Intra
UBXN2A P68543 VCP Homo sapiens P55072
BRET
29997244
Intra
UBXN2A P68543 VCP Homo sapiens P55072
Y2H Array
32814053
Intra
UBXN2A P68543 VCP Homo sapiens P55072
Anti Tag CoIP
33961781
Intra
UBXN2A P68543 VCP Homo sapiens P55072
Y2H Array
32296183
Intra
UBXN2A P68543 VCP Homo sapiens P55072
Anti Tag CoIP
28514442
Intra
UBXN2A P68543 VCP Homo sapiens P55072
Lumier
29997244
Intra
UBXN2A P68543 DYDC2 Homo sapiens Q96IM9
Validated Y2H
32296183
Intra
UBXN2A P68543 DYDC2 Homo sapiens Q96IM9
Y2H Array
32296183
Intra
UBXN2A P68543 DYDC2 Homo sapiens Q96IM9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15396 UBXN2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBXN2A VGNC VGNC:79657
Canis familiaris UBXN2A VGNC VGNC:48098
Mus musculus UBXN2A MGD MGI:2442310
Felis catus UBXN2A VGNC VGNC:66792
Bos taurus UBXN2A VGNC VGNC:36625
Rattus norvegicus UBXN2A RGD RGD:1589027
Others UBXN2A NCBI