PSMD9 - proteasome 26S subunit, non-ATPase 9 Gene

Also Known as p27; Rpn4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5715

About PSMD9

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,888,790-121,918,297 (from NCBI)

This gene has 11 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in bone marrow (RPKM 16.1), kidney (RPKM 11.1) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

PSMD9 Products (2)

mRNA Protein Name
NM_001261400.3 NP_001248329.1 26S proteasome non-ATPase regulatory subunit 9 isoform 2
NM_002813.7 NP_002804.2 26S proteasome non-ATPase regulatory subunit 9 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in proteasome regulatory particle assembly IMP
IMP: Inferred from mutant phenotype
19490896 GOA
Cellular Component GO Annotation Evidence References Source
part of proteasome regulatory particle, base subcomplex IDA
IDA: Inferred from direct assay
19490896 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD9 Protein Structure

PDZ_2

PDZ_2: PDZ domain (137 - 201)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

26S proteasome non-ATPase regulatory subunit 9

  • 26S proteasome regulatory subunit p27

PSMD9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PSMD9 O00233 KLKB1 Homo sapiens P03952
Validated Y2H
32814053
Intra
PSMD9 O00233 KLKB1 Homo sapiens P03952
Y2H Array
32814053
Intra
PSMD9 O00233 KLKB1 Homo sapiens P03952
Y2H Pooling
32814053
Intra
PSMD9 O00233 CCDC136 Homo sapiens Q96JN2-2
Validated Y2H
25416956
Intra
PSMD9 O00233 CCDC136 Homo sapiens Q96JN2-2
Y2H Array
25416956
Intra
PSMD9 O00233 CEP85L Homo sapiens Q5SZL2-5
Y2H Prey Pooling
32296183
Intra
PSMD9 O00233 CEP85L Homo sapiens Q5SZL2-5
Validated Y2H
32296183
Intra
PSMD9 O00233 CEP85L Homo sapiens Q5SZL2-5
Y2H Array
32296183
Intra
PSMD9 O00233 CSH1 Homo sapiens P0DML2
Anti Tag CoIP
25009770
Intra
PSMD9 O00233 CSH1 Homo sapiens P0DML2
Pull Down
25009770
Intra
PSMD9 O00233 CSH1 Homo sapiens P0DML2
ELISA
25009770
Intra
PSMD9 O00233 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
PSMD9 O00233 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
PSMD9 O00233 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
PSMD9 O00233 IL6R Homo sapiens P08887-2
ELISA
25009770
Intra
PSMD9 O00233 IL6R Homo sapiens P08887-2
Pull Down
25009770
Intra
PSMD9 O00233 AHCYL1 Homo sapiens O43865
Validated Y2H
25416956
Intra
PSMD9 O00233 AHCYL1 Homo sapiens O43865
Y2H Array
25416956
Intra
PSMD9 O00233 HNRNPA1 Homo sapiens P09651-2
Anti Tag CoIP
25009770
Intra
PSMD9 O00233 HNRNPA1 Homo sapiens P09651-2
Pull Down
25009770
Intra
PSMD9 O00233 HNRNPA1 Homo sapiens P09651-2
ELISA
25009770
Intra
PSMD9 O00233 RPS14 Homo sapiens P62263
Anti Tag CoIP
25009770
Intra
PSMD9 O00233 RPS14 Homo sapiens P62263
ELISA
25009770
Intra
PSMD9 O00233 RPS14 Homo sapiens P62263
Pull Down
25009770
Intra
PSMD9 O00233 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
PSMD9 O00233 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
PSMD9 O00233 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
PSMD9 O00233 PSMC6 Homo sapiens P62333
Validated Y2H
25416956
Intra
PSMD9 O00233 PSMC6 Homo sapiens P62333
Y2H
21516116
Intra
PSMD9 O00233 PSMC6 Homo sapiens P62333
Validated Y2H
32296183
Intra
PSMD9 O00233 PSMC6 Homo sapiens P62333
Anti Tag CoIP
33961781
Intra
PSMD9 O00233 PSMC6 Homo sapiens P62333
Y2H Array
32296183
Intra
PSMD9 O00233 PSMC6 Homo sapiens P62333
Y2H Prey Pooling
25416956
Intra
PSMD9 O00233 PSMC6 Homo sapiens P62333
Y2H Prey Pooling
32296183
Intra
PSMD9 O00233 PSMC6 Homo sapiens P62333
Anti Tag CoIP
19490896
Intra
PSMD9 O00233 PSMC6 Homo sapiens P62333
Anti Tag CoIP
35271311
Intra
PSMD9 O00233 PSMC3 Homo sapiens P17980
Validated Y2H
25416956
Intra
PSMD9 O00233 PSMC3 Homo sapiens P17980
Validated Y2H
32296183
Intra
PSMD9 O00233 PSMC3 Homo sapiens P17980
Y2H Array
25416956
Intra
PSMD9 O00233 PSMC3 Homo sapiens P17980
Y2H Prey Pooling
32296183
Intra
PSMD9 O00233 PSMC3 Homo sapiens P17980
Y2H Array
32296183
Intra
PSMD9 O00233 PSMC3 Homo sapiens P17980
Anti Tag CoIP
19490896
Intra
PSMD9 O00233 PSMC3 Homo sapiens P17980
Anti Tag CoIP
33961781
Intra
PSMD9 O00233 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
25416956
Intra
PSMD9 O00233 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
25416956
Intra
PSMD9 O00233 LPL Homo sapiens P06858
Y2H Array
32814053
Intra
PSMD9 O00233 LPL Homo sapiens P06858
Y2H Pooling
32814053
Intra
PSMD9 O00233 LPL Homo sapiens P06858
Validated Y2H
32814053
Intra
PSMD9 O00233 TRIM39 Homo sapiens Q9HCM9
Y2H Prey Pooling
25416956
Intra
PSMD9 O00233 BANP Homo sapiens Q8N9N5
Y2H Prey Pooling
25416956
Intra
PSMD9 O00233 BANP Homo sapiens Q8N9N5
Y2H Array
25416956
Intra
PSMD9 O00233 NCKIPSD Homo sapiens Q9NZQ3
Y2H Prey Pooling
25416956
Intra
PSMD9 O00233 NCKIPSD Homo sapiens Q9NZQ3
Validated Y2H
25416956
Intra
PSMD9 O00233 TCF3 Homo sapiens P15923-1
Pull Down
25009770
Intra
PSMD9 O00233 TCF3 Homo sapiens P15923-1
ELISA
25009770
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Carpal Tunnel Syndrome

  • Cts

  • Carpal Tunnel Syndrome, Familial

  • Carpal Tunnel Syndrome 1

  • CTS1

  • Amyotrophy, Thenar, Of Carpal Origin

  • Carpal Tunnel Median Neuropathy

  • Cts - Carpal Tunnel Syndrome

  • Median Nerve Entrapment

  • Carpal Canal

  • Carpal Tunnel

  • Compression Neuropathy, Carpal Tunnel

  • Distal Median Nerve Compression

  • Distal Median Nerve Entrapment

  • Entrapment Neuropathy, Carpal Tunnel

  • Median Neuropathy, Carpal Tunnel

  • Median Neuropathy Carpal Tunnel

  • Thenar Amyotrophy Of Crapal Origin
Maturity-Onset Diabetes Of The Young, Type 3

  • Maturity-Onset Diabetes Of The Young Type 3

  • MODY3

  • Mody, Type Iii

  • Mody Type 3

  • Mody, Type 3

  • Maturity-Onset Diabetes Of The Young 3

  • Mody-3

  • Diabetes Of The Young, Maturity-Onset, Type 3
Histrionic Personality Disorder
Nerve Compression Syndrome

  • Entrapment Neuropathies

  • Compression Neuropathy

  • Entrapment Neuropathy

  • Peripheral Nerve Entrapment Syndrome

  • Nerve Compression Syndromes

  • Hereditary Liability To Pressure Palsies
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11330 PSMD9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PSMD9 VGNC VGNC:52958
Bos taurus PSMD9 VGNC VGNC:53917
Rattus norvegicus PSMD9 RGD RGD:621110
Mus musculus PSMD9 MGD MGI:1914401
Macaca mulatta PSMD9 VGNC VGNC:84901
Felis catus PSMD9 VGNC VGNC:80467
Others PSMD9 NCBI