NCKIPSD - NCK interacting protein with SH3 domain Gene

Also Known as DIP; DIP1; ORF1; WISH; VIP54; AF3P21; SPIN90; WASLBP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51517

Summary

The protein encoded by this gene contains a nuclear localization signal. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation This protein is involved in the formation and maintenance of dendritic spines, and modulates synaptic activity in neurons. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2019]
Ubiquitous expression in ovary (RPKM 9.3), brain (RPKM 7.3) and 25 other tissues.

NCKIPSD Products (2)

mRNA Protein Name
NM_016453.4 NP_057537.1 NCK-interacting protein with SH3 domain isoform 1
NM_184231.3 NP_909119.1 NCK-interacting protein with SH3 domain isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15095401 GOA
Cellular Component GO Annotation Evidence References Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCKIPSD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NCKIPSD Q9NZQ3 PALLD Homo sapiens Q8WX93
Anti Tag CoIP
33961781
Intra
NCKIPSD Q9NZQ3 FYN Homo sapiens P06241
Peptide Array
17474147
Intra
NCKIPSD Q9NZQ3 BAIAP2 Homo sapiens Q9UQB8
Anti Tag CoIP
33961781
Intra
NCKIPSD Q9NZQ3 BAIAP2 Homo sapiens Q9UQB8
Anti Bait CoIP
19460367
Intra
NCKIPSD Q9NZQ3 SORBS3 Homo sapiens O60504
Validated Y2H
25416956
Intra
NCKIPSD Q9NZQ3 SORBS3 Homo sapiens O60504
Y2H Array
25416956
Intra
NCKIPSD Q9NZQ3 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
25416956
Intra
NCKIPSD Q9NZQ3 PSMD9 Homo sapiens O00233
Y2H Array
25416956
Intra
NCKIPSD Q9NZQ3 PSMD9 Homo sapiens O00233
Y2H Array
31515488
Cross
NCKIPSD Q9NZQ3 Pacsin1 Rattus norvegicus Q9Z0W5
Affinity Chrom
16999739
Cross
NCKIPSD Q9NZQ3 Pacsin1 Rattus norvegicus Q9Z0W5
Pull Down
16999739
Cross
NCKIPSD Q9NZQ3 BAIAP2 Cricetulus griseus Q60437
Pull Down
19460367
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCKIPSD Proteins

Cat. No. Product Name Accession Purity
HY-P77099 NCKIPSD Protein, Human (His) Q9NZQ3-3 (M1-T244) ≥ 95%, as determined by reducing SDS-PAGE.