UBXN1 - UBX domain protein 1 Gene

Also Known as 2B28; SAKS1; UBXD10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51035

About UBXN1

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,676,500-62,679,073 (from NCBI)

This gene has 18 transcripts (splice variants), 197 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 47.6), fat (RPKM 40.5) and 25 other tissues.

Summary

Enables several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and Proteasome regulatory particle binding activity. Involved in negative regulation of cellular protein metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]

UBXN1 Products (3)

mRNA	Protein	Name
NM_001286077.2	NP_001273006.1	UBX domain-containing protein 1 isoform 2
NM_001286078.2	NP_001273007.1	UBX domain-containing protein 1 isoform 3
NM_015853.5	NP_056937.2	UBX domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	15362974	GOA
enables K48-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	21135095	GOA
enables K6-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	20351172	GOA
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	15362974	GOA
enables proteasome regulatory particle binding	IDA IDA: Inferred from direct assay	15362974	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18775313	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	18775313	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	18775313	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	21135095	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	20351172	GOA
involved in negative regulation of protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	21135095	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	20351172	GOA
involved in negative regulation of ubiquitin-specific protease activity	IDA IDA: Inferred from direct assay	21135095	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of VCP-NPL4-UFD1 AAA ATPase complex	IDA IDA: Inferred from direct assay	18775313	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10942595	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21135095	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21135095	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBXN1 Protein Structure

UBA

UBX

0
100
200
297 a.a.

Protein Preferred Names	Protein Names
UBX domain-containing protein 1	SAPK substrate protein 1

UBXN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBXN1	Q04323	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	UBXN1	Q04323	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	UBXN1	Q04323	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	UBXN1	Q04323	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	25416956
Intra	UBXN1	Q04323	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	25416956
Intra	UBXN1	Q04323	PLAA	Homo sapiens	Q9Y263	Y2H Array	25416956
Intra	UBXN1	Q04323	PLAA	Homo sapiens	Q9Y263	Anti Tag CoIP	18775313
Intra	UBXN1	Q04323	VCP	Homo sapiens	P55072	Anti Tag CoIP	18775313
Intra	UBXN1	Q04323	VCP	Homo sapiens	P55072	Y2H Array	25416956
Intra	UBXN1	Q04323	VCP	Homo sapiens	P55072	Validated Y2H	25416956
Intra	UBXN1	Q04323	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	25416956
Intra	UBXN1	Q04323	TRIM39	Homo sapiens	Q9HCM9	Validated Y2H	25416956
Intra	UBXN1	Q04323	q8wu02_human	Homo sapiens	Q8WU02	Y2H Prey Pooling	25416956
Intra	UBXN1	Q04323	q8wu02_human	Homo sapiens	Q8WU02	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Ibmpfd Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia Pagetoid Amyotrophic Lateral Sclerosis Pagetoid Neuroskeletal Syndrome Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia Multisystem Proteinopathy Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement Lower Motor Neuron Degeneration With Paget-Like Bone Disease Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15394	UBXN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22894	Ubxn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29408	Ubxn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBXN1	MGD	MGI:1289301
Bos taurus	UBXN1	VGNC	VGNC:36622
Rattus norvegicus	UBXN1	RGD	RGD:1309471
Canis familiaris	UBXN1	VGNC	VGNC:48095
Macaca mulatta	UBXN1	VGNC	VGNC:79135
Felis catus	UBXN1	VGNC	VGNC:66790
Others	UBXN1	NCBI