PLAA - phospholipase A2 activating protein Gene

Also Known as DOA1; PLAP; PLA2P; NDMSBA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9373

About PLAA

Cytogenetic location: 9p21.2 Genomic coordinates (GRCh38): 9:26,903,372-26,947,242 (from NCBI)

This gene has 7 transcripts (splice variants), 209 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 6.9), bone marrow (RPKM 5.3) and 25 other tissues.

Summary

Predicted to enable ubiquitin binding activity. Involved in cellular response to lipopolysaccharide; macroautophagy; and positive regulation of Phospholipase A2 activity. Located in cytoplasm; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PLAA Products (2)

mRNA Protein Name
NM_001031689.3 NP_001026859.1 phospholipase A-2-activating protein isoform 1
NM_001321546.2 NP_001308475.1 phospholipase A-2-activating protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18775313 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
28007986 GOA
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
27753622 GOA
involved in positive regulation of phospholipase A2 activity IMP
IMP: Inferred from mutant phenotype
28007986 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
27753622 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
17076679 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28007986 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAA Protein Structure

WD40

WD40: WD domain, G-beta repeat (13 - 46)

WD40

WD40: WD domain, G-beta repeat (61 - 98)

WD40

WD40: WD domain, G-beta repeat (104 - 138)

WD40

WD40: WD domain, G-beta repeat (142 - 179)

WD40

WD40: WD domain, G-beta repeat (181 - 217)

WD40

WD40: WD domain, G-beta repeat (221 - 259)

PFU

PFU: PFU (PLAA family ubiquitin binding) (345 - 459)

PUL

PUL: PUL domain (534 - 789)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
Protein Preferred Names Protein Names

phospholipase A-2-activating protein

  • DOA1 homolog

PLAA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLAA Q9Y263 UBXN1 Homo sapiens Q04323
Y2H Prey Pooling
25416956
Intra
PLAA Q9Y263 UBXN1 Homo sapiens Q04323
Validated Y2H
25416956
Intra
PLAA Q9Y263 UBXN1 Homo sapiens Q04323-2
Y2H Prey Pooling
32296183
Intra
PLAA Q9Y263 UBXN1 Homo sapiens Q04323-2
Y2H Array
32296183
Intra
PLAA Q9Y263 VCP Homo sapiens P55072
Y2H Prey Pooling
32296183
Intra
PLAA Q9Y263 VCP Homo sapiens P55072
Y2H Array
25416956
Intra
PLAA Q9Y263 VCP Homo sapiens P55072
Y2H Array
32296183
Intra
PLAA Q9Y263 VCP Homo sapiens P55072
Y2H Prey Pooling
25416956
Intra
PLAA Q9Y263 KPNA4 Homo sapiens O00629
Y2H Prey Pooling
25416956
Intra
PLAA Q9Y263 KPNA4 Homo sapiens O00629
Validated Y2H
25416956
Cross
PLAA Q9Y263 q76353_9hiv1 Human immunodeficiency virus Q76353
Pull Down
22190034
Intra
PLAA Q9Y263 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
PLAA Q9Y263 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

PLAA Antibodies

Cat. No. Product Name Application Reactivity
HY-P83089 Phospholipase A2 Activator Protein Antibody (YA2834) WB, IHC-P, ICC/IF, IP Human

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies

  • NDMSBA

  • Plaa-Associated Neurodevelopmental Disorder

  • Plaand
Split-Hand/Foot Malformation 1

  • Ectrodactyly

  • Split Hand-Foot Malformation 1

  • SHFM1

  • Shfd1

  • Split-Hand Deformity

  • Split-Hand/Foot Malformation 1 With Or Without Deafness

  • Split-Hand/Foot Deformity 1

  • Ecd

  • Split Hand/Foot Malformation Type 1

  • Split Hand Foot Deformity 1

  • Split-Hand/Foot Malformation
Lymphoproliferative Syndrome

  • Lymphoproliferative Disorder

  • Lymphoproliferative Disorders

  • Lymphoproliferative Disorders, Susceptibility To
Combined T And B Cell Immunodeficiency
Combined Immunodeficiency

  • Combined T Cell And B Cell Immunodeficiency

  • Congenital Combined Immunodeficiency

  • Syndrome With Combined Immunodeficiency

  • Combined T And B Cell Immunodeficiency

  • Combined Immunity Deficiency

  • Combined Immunodeficiency Syndrome

  • Combined T-Cell And B-Cell Immunodeficiency

  • Lymphopenic Agammaglobulinaemia
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Conjugate Gaze Palsy

  • Palsy Of Conjugate Gaze

  • Supranuclear Ocular Palsy

  • Gaze Palsy
Peho Syndrome

  • Progressive Encephalopathy With Edema, Hypsarrhythmia, And Optic Atrophy

  • Infantile Cerebellooptic Atrophy

  • PEHO

  • Progressive Encephalopathy With Edema, Hypsarrhythmia And Optic Atrophy

  • Progressive Encephalopathy-Optic Atrophy Syndrome
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

  • Ibmpfd

  • Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

  • Pagetoid Amyotrophic Lateral Sclerosis

  • Pagetoid Neuroskeletal Syndrome

  • Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

  • Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

  • Multisystem Proteinopathy

  • Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

  • Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

  • Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

  • Lower Motor Neuron Degeneration With Paget-Like Bone Disease

  • Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

  • Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10636 PLAA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PLAA VGNC VGNC:44634
Bos taurus PLAA VGNC VGNC:32967
Rattus norvegicus PLAA RGD RGD:621245
Mus musculus PLAA MGD MGI:104810
Felis catus PLAA VGNC VGNC:68886
Others PLAA NCBI