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CD207 - CD207 molecule Gene

Also Known as CLEC4K

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50489

About CD207

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,824,130-70,835,816 (from NCBI)

This gene has 1 transcript (splice variant), 877 orthologues, 14 paralogues and is associated with 1 phenotype. Biased expression in skin (RPKM 26.1), esophagus (RPKM 6.2) and 1 other tissue.

Summary

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

CD207 Products (1)

mRNA	Protein	Name
NM_015717.5	NP_056532.4	C-type lectin domain family 4 member K

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables carbohydrate binding	IDA IDA: Inferred from direct assay	20026605	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in defense response to virus	IDA IDA: Inferred from direct assay	17334373	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD207 Protein Structure

Lectin_C

0
100
200
300
328 a.a.

Protein Preferred Names	Protein Names
C-type lectin domain family 4 member K	C-type lectin domain family 4, member K

CD207 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD207	Q9UJ71	GRAMD2B	Homo sapiens	Q96HH9	Y2H Array	32296183
Intra	CD207	Q9UJ71	GRAMD2B	Homo sapiens	Q96HH9	Y2H Prey Pooling	32296183
Intra	CD207	Q9UJ71	GRAMD2B	Homo sapiens	Q96HH9	Validated Y2H	25910212
Intra	CD207	Q9UJ71	GRAMD2B	Homo sapiens	Q96HH9	Y2H Bait-Prey Pool	25910212
Intra	CD207	Q9UJ71	GRAMD2B	Homo sapiens	Q96HH9	Y2H Array	25910212
Intra	CD207	Q9UJ71	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	CD207	Q9UJ71	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212
Intra	CD207	Q9UJ71	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	CD207	Q9UJ71	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Prey Pooling	32296183
Intra	CD207	Q9UJ71	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Array	32296183
Intra	CD207	Q9UJ71	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	CD207	Q9UJ71	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	CD207	Q9UJ71	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD207 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7819	Langerin/CD207 Protein, Human (HEK293, His)	AAH22278.1 (Y64-P328)	≥ 95%, as determined by reducing SDS-PAGE.

CD207 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81521	Langerin Antibody (YA1266)	IHC-P	Human
HY-P81521A	Langerin Antibody (YA1266)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Birbeck Granule Deficiency	Birbeck Granules, Absence Of BIRGD Absence Of Birbeck Granules
Langerhans Cell Sarcoma	Malignant Langerhans Cell Sarcoma
Histiocytosis	Chronic Histiocytosis X Hand Schuller Christian Disease Hand-Schüller-Christian Disease Histiocytic Syndrome Histiocytosis, Langerhans-Cell
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Follicular Dendritic Cell Sarcoma	Dendritic Cell Sarcoma Dendritic Cell Sarcoma, Follicular Follicular Dendritic Cell Tumour Dendritic Cell Sarcoma, Interdigitating Dendritic Cell Sarcoma, Not Otherwise Specified
Non-Langerhans-Cell Histiocytosis	Histiocytosis, Non-Langerhans-Cell Non-Langerhans Cell Histiocytosis
Reticulohistiocytic Granuloma	Reticulohistiocytoma Solitary Reticulohistiocytoma Solitary Histiocytoma Solitary Reticulohistiocytosis
Histiocytic And Dendritic Cell Cancer	Histiocytic And Dendritic Cell
Juvenile Xanthogranuloma	Multiple Eruptive Juvenile Xanthogranuloma Naevoxanthoendothelioma Xanthoma Neviforme Xanthogranuloma, Juvenile
Vulvar Proximal-Type Epithelioid Sarcoma
Central Epithelioid Sarcoma	Proximal-Type Epithelioid Sarcoma
Adult Xanthogranuloma
Interdigitating Dendritic Cell Sarcoma	Interdigitating Cell Sarcoma Dendritic Cell Sarcoma, Interdigitating Reticulum Cell Sarcoma
Frontal Sinus Benign Neoplasm	Neoplasm Of Frontal Sinus Tumor Of The Frontal Sinus
Seborrheic Dermatitis	Seborrhoeic Dermatitis Seborrhea Seborrhoeic Eczema Skin Seborrheic Dermatitis, Seborrheic
Beach Ear	Acute Swimmer'S Ear Acute Bacterial Inflammation Of External Ear Acute Otitis Externa, Diffuse Acute Swimmers' Ear Tank Ear
Rhinoscleroma
Fibrosarcoma Of Bone	Malignant Histiocytosis Malignant Fibroxanthoma Malignant Fibrous Histiocytoma Histiocytic Medullary Reticulosis Nasal Type Extranodal Nk/T-Cell Lymphoma Histiocytic Sarcoma
Cavernous Sinus Meningioma	Meningioma Of The Cavernous Sinus
Otorrhea	Discharging Ear
Malignant Histiocytic Disease	Histiocytic Disorders, Malignant
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02208	CD207 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18651	Cd207 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25137	Cd207 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CD207	VGNC	VGNC:27011
Rattus norvegicus	CD207	RGD	RGD:1565913
Felis catus	CD207	VGNC	VGNC:60596
Mus musculus	CD207	MGD	MGI:2180021
Canis familiaris	CD207	VGNC	VGNC:54285
Macaca mulatta	CD207	VGNC	VGNC:70818
Others	CD207	NCBI