2. Metabolic Enzyme/Protease
  3. Stearoyl-CoA Desaturase (SCD)
  4. Sterculic acid

Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC50 value of 0.9 μM.

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Sterculic acid Chemical Structure

Sterculic acid Chemical Structure

CAS No. : 738-87-4

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Based on 1 publication(s) in Google Scholar

Sterculic acid Related Antibodies

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Description

Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC50 value of 0.9 μM[1].

IC50 & Target[1]

delta-9 desaturase

0.9 μM (IC50)

In Vitro

Sterculic acid (SA) is a cyclopropene fatty acid originally found in the seeds of the plant Sterculia foetida with numerous biological activities[2].
Sterculic acid is able to reduce adrenomedullin expression (AP, RP, APS, IML, in preparation)[2].
Sterculic acid is also able to mediate anti-inflammatory and protective effects[2].
Sterculic acid has a potent luteolytic effect in ovines by inhibition in the synthesis of progesterone, which causes luteal regression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sterculic acid Related Antibodies
In Vivo

Sterculic acid has been proposed as a potential tool for the treatment of metabolic syndrome (MS) since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1) in vivo[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

294.47

Formula

C19H34O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCCCCCC1=C(C1)CCCCCCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 10 mg/mL (33.96 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Ethanol : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3959 mL 16.9797 mL 33.9593 mL
5 mM 0.6792 mL 3.3959 mL 6.7919 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (238 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 3.3959 mL 16.9797 mL 33.9593 mL 84.8983 mL
5 mM 0.6792 mL 3.3959 mL 6.7919 mL 16.9797 mL
10 mM 0.3396 mL 1.6980 mL 3.3959 mL 8.4898 mL
15 mM 0.2264 mL 1.1320 mL 2.2640 mL 5.6599 mL
20 mM 0.1698 mL 0.8490 mL 1.6980 mL 4.2449 mL
25 mM 0.1358 mL 0.6792 mL 1.3584 mL 3.3959 mL
30 mM 0.1132 mL 0.5660 mL 1.1320 mL 2.8299 mL
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Sterculic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sterculic acid738-87-4Stearoyl-CoA Desaturase (SCD)sterculic acidinflammationmetabolic syndromestearoyl-CoA desaturase-1SCD1delta-9 desaturaseΔ9DInhibitorinhibitorinhibit

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