Preventive Action of Sterculic Oil on Metabolic Syndrome Development on a Fructose-Induced Rat Model

  • J Med Food. 2020 Mar;23(3):305-311. doi: 10.1089/jmf.2019.0177.
Abril Ramírez-Higuera  1 ,  Carolina Peña-Montes  1 ,  Socorro Herrera-Meza  2 ,  Remedios Mendoza-López  3 ,  Gerardo Valerio-Alfaro  1 ,  Rosa María Oliart-Ros  1
Affiliations
  • 1. National Tech of México (Tecnológico Nacional de México)/I.T. Veracruz, Food Research and Development Unit (UNIDA), Veracruz, México.
  • 2. Institute of Psychological Research, University of Veracruz, Xalapa, Veracruz, México.
  • 3. Unit of Support Services in Analytical Resolution, Xalapa, Veracruz, México.
PMID: 31663815 DOI: 10.1089/jmf.2019.0177
Abstract

The metabolic syndrome (MS) underlies metabolic disorders considered risk factors for the development of diabetes and cardiovascular diseases, which are major causes of morbidity and mortality in most of the world. Sterculic acid has been proposed as a potential tool for the treatment of MS since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1), a central enzyme in lipid metabolism. We analyzed the effect of sterculic oil (SO) co-administration with 30% fructose in drinking water on the development of MS in male Wistar rats. After 8 weeks, 0.4% SO exerted a protective effect from MS development since parameters altered by fructose (blood pressure, Insulin resistance, serum glucose and triglycerides, steatosis, and adiposity) were similar to those of control rats.

Keywords
Sterculia apetala; cyclopropene fatty acids; fructose-induced model; metabolic syndrome; stearoyl-CoA desaturase; sterculic oil.
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