SCD1

By Targets:	Bacterial (1) Histone Methyltransferase (1) Influenza Virus (1) Small Interfering RNA (siRNA) (1) Stearoyl-CoA Desaturase (SCD) (16) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (9) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141525

SCD1 inhibitor-4	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
SCD1 inhibitor-4 is a potent, orally active stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes ^[1].

HY-112812

SCD1 inhibitor-1

Stearoyl-CoA Desaturase (SCD) Metabolic Disease Cancer

SCD1 inhibitor-1 is a potent and liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitor ^[1].

SCD1 inhibitor-1	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease Cancer
SCD1 inhibitor-1 is a potent and liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitor ^[1].

HY-139077

SCD1 inhibitor-3	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease Cancer
SCD1 inhibitor-3 is a safe, potent and orally active *SCD1* inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer ^[1].

HY-RS12496

Scd1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Scd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Scd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Scd1 Mouse Pre-designed siRNA Set A Scd1 Mouse Pre-designed siRNA Set A

HY-150125

SCD1-IN-1

Stearoyl-CoA Desaturase (SCD) Inflammation/Immunology

SCD1-IN-1 is a SCD1 inhibitor (IC₅₀: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition ^[1].
HY-155403

SCD1/5-IN-1

Stearoyl-CoA Desaturase (SCD) Neurological Disease

SCD1/5-IN-1 (Compound 10) is a SCD1/5 inhibitor. SCD1/5-IN-1 can be used for research of neurological disease ^[1].

SCD1-IN-1	Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
SCD1-IN-1 is a *SCD1* inhibitor (IC₅₀: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition ^[1].

SCD1/5-IN-1	Stearoyl-CoA Desaturase (SCD)	Neurological Disease
SCD1/5-IN-1 (Compound 10) is a *SCD1/5* inhibitor. SCD1/5-IN-1 can be used for research of neurological disease ^[1].

HY-13077

MK-8245 Trifluoroacetate 3 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.

HY-13070

MK-8245 3 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC₅₀s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy ^[1].

HY-155033

SSI-4	Stearoyl-CoA Desaturase (SCD)	Others
SSI-4 is an inhibitor of Stearoyl CoA desaturase 1 (SCD1) , which can be modified with ¹¹C, used as a ligand to in vivo small animal PET/CT imaging of SCD1 ^[1].

HY-127143

Sterculic acid	Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC₅₀ value of 0.9 μM ^[1].

HY-15822

MF-438 3 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC₅₀ of 2.3 nM for rSCD1 ^[1].

HY-N6807

Elemicin	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial	Infection Cancer
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity ^[1] .

HY-12756A

E6446 dihydrochloride 1 Publications Verification
E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent *SCD1* inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) ^[1] .

HY-12756

E6446 1 Publications Verification	Toll-like Receptor (TLR) Stearoyl-CoA Desaturase (SCD)	Metabolic Disease Inflammation/Immunology
E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent *SCD1* inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) ^[1] .

HY-50709

A939572 Maximum Cited Publications 29 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Cancer
A939572 is a potent, and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC₅₀ values of <4 nM and 37 nM for *mSCD1* and *hSCD1*, respectively.

HY-100249

XEN723	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC₅₀s of 45 and 524 nM in mouse and HepG2 cell, respectively.

HY-19796

Icomidocholic acid 1 Publications Verification Aramchol; C20-FABAC
Icomidocholic acid (Aramchol) is a conjugate of cholic acid and arachidic acid that could inhibit stearoyl coenzyme A desaturase 1 (SCD1) activity. Icomidocholic acid has potential use in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) treatment ^[1].

HY-124751

YTX-465	Stearoyl-CoA Desaturase (SCD)	Neurological Disease
YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC₅₀s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies ^[1].

HY-15823

CAY10566 5+ Cited Publications	Stearoyl-CoA Desaturase (SCD)	Cancer
CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC₅₀s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. CAY10566 also shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC₅₀=7.9 nM or 6.8 nM) ^[1] .

HY-152775A

RK-0133114	Histone Methyltransferase	Metabolic Disease
RK-0133114 is a G9a inhibitor and a R-enantiomer of RK-701 (HY-152775). RK-0133114 inhibits G9a with an IC₅₀ value of 3.7 μM. RK-0133114 can be used for the research of sickle cell disease (SCD) .

HY-N8144

Niga-ichigoside F1	Others	Cardiovascular Disease
Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-127143

Sterculic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Sterculiaceae Plants Inflammation/Immunology Disease Research Fields Sterculia foetida Linn.	Stearoyl-CoA Desaturase (SCD)
Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC₅₀ value of 0.9 μM ^[1].

HY-N6807

Elemicin	Infection Asarum sieboldii Miq. Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Disease Research Fields Aristolochiaceae	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity ^[1] .

HY-N8144

Niga-ichigoside F1	Cardiovascular Disease Triterpenes Inula sericophylla Franch. Classification of Application Fields Terpenoids Labiatae Source classification Plants Disease Research Fields	Others
Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis ^[1].

Cat. No.	Compare	Product Name	Species	Source

HY-P702429

	SCD1 Protein, Mouse (Cell-Free, His) Acyl-CoA desaturase 1; Delta(9)-desaturase 1; Delta-9 desaturase 1; Fatty acid desaturase 1; Stearoyl-CoA desaturase 1	Mouse	E. coli Cell-free
	The SCD1 protein or stearoyl-CoA desaturase 1 utilizes O(2) and electrons to introduce the first double bond into a saturated fatty acyl-CoA substrate. This process produces an important mixture of 16:1 and 18:1 unsaturated fatty acids, essential for lipid biosynthesis. SCD1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived SCD1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SCD1 Protein, Mouse (Cell-Free, His) is 355 a.a., with molecular weight of 43.9 kDa.


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HY-P81418

SCD1 Antibody (YA1163)

SCD1; FADS5; SCDOS; MSTP008
IHC-P Human

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