1. Saccharides and Glycosides
    Terpenoids and Glycosides
  2. Niga-ichigoside F1

Niga-ichigoside F1 

Cat. No.: HY-N8144
Handling Instructions

Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis.

For research use only. We do not sell to patients.

Niga-ichigoside F1 Chemical Structure

Niga-ichigoside F1 Chemical Structure

CAS No. : 95262-48-9

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Description

Niga-ichigoside F1, an orally active ursane triterpenoid, has antihyperlipidemic and antioxidant activities. Niga-ichigoside F1 can prevent high-fat diet (HFD)-induced hepatic steatosis[1].

In Vitro

Niga-ichigoside F1 (2.5, 5, 10, 20 μM; for 24 hours) inhibits lipid accumu-lation in free fatty acid (FFA)-treated HepG2 cells in a dose-dependent manner. Niga-ichigoside F1 has no effects on cell viability[1].
Both nuclear and cytoplasmic Nrf2 expressions are lowered in Con, Niga-ichigoside F1 (20 μM), FFA (1 mM), and Niga-ichigoside F1 plus FFA treated Nrf2-silenced cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Niga-ichigoside F1 (40 mg/kg; oral gavage; for 12 weeks) alleviates hepatic steatosis, possibly by significantly interacting with high-fat diet (HFD) to regulate lipid metabolism genes (including Srebp1c, Acc1, Fasn, Scd1, Cpt1a and Fabp5) in four-week-old male C57BL/6J mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

666.84

Formula

C₃₆H₅₈O₁₁

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Niga-ichigoside F1
Cat. No.:
HY-N8144
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