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Art. -Nr.: HY-114606

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SW208108

SW208108 is a prodrug of dMe-SW208108, a CYP4F11-activated SCD inhibitor, with an IC₅₀ value of 9 nM. SW208108 undergoes demethylation by CYP4F11 to form the active metabolite dMe-SW208108, thereby inhibiting enzyme function. SW208108 depletes unsaturated fatty acids, induces cytotoxicity in non-small cell lung cancer (NSCLC) cells expressing CYP4F11, and does not affect SCD activity in mouse sebocytes. SW208108 can be used in studies related to NSCLC.

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CAS. Nr.: 1673557-43-1
Formel: C₂₇H₂₄N₂O₅
Molecular Weight:456.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

SW208108 Chemical Structure

CAS. Nr.: 1673557-43-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1155	EC₅₀	16 μM Compound: 15	Cytotoxicity against human NCI-H1155 cells incubated for 4 days in presence of sodium oleate Cytotoxicity against human NCI-H1155 cells incubated for 4 days in presence of sodium oleate	[PMID: 29869888]
NCI-H1155	EC₅₀	0.12 μM Compound: 15	Cytotoxicity against human NCI-H1155 cells expressing CYP4F11 incubated for 4 days Cytotoxicity against human NCI-H1155 cells expressing CYP4F11 incubated for 4 days	[PMID: 29869888]
NCI-H1155	EC₅₀	8.5 μM Compound: 15	Cytotoxicity against human NCI-H1155 cells expressing pLVX empty vector incubated for 4 days Cytotoxicity against human NCI-H1155 cells expressing pLVX empty vector incubated for 4 days	[PMID: 29869888]
NCI-H1155	EC₅₀	50 μM Compound: 15	Cytotoxicity against human NCI-H1155 cells expressing CYP4F11 incubated for 4 days in presence of sodium oleate Cytotoxicity against human NCI-H1155 cells expressing CYP4F11 incubated for 4 days in presence of sodium oleate	[PMID: 29869888]
NCI-H2122	EC₅₀	0.028 μM Compound: 15	Cytotoxicity against human NCI-H2122 cells incubated for 4 days Cytotoxicity against human NCI-H2122 cells incubated for 4 days	[PMID: 29869888]

In Vitro

Anti-cancerLipid Metabolism

Anti-cancer

SW208108 selectively reduces the viability of four NSCLC cell lines (H2122, H460, HCC44, HCC4017) with an IC₅₀ of 0.014-0.031 μM; it exhibits moderate toxicity against H2073 cells, but shows no toxicity against another seven NSCLC cell lines^[1].

Lipid Metabolism

SW208108 is selectively metabolized to dMe-SW208108 in H2122 non-small cell lung cancer cells, whereas it remains unmetabolized in H1155 non-small cell lung cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 1673557-43-1
Molecular Weight 456.50
Formel C₂₇H₂₄N₂O₅
SMILES

O=C(NC1=CC=C(C=C1)C(=O)C2=CC=C(OCC#C)C=C2)C(=O)NCCC3=CC=C(OC)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Theodoropoulos PC, et al. Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Nature chemical biology. 2016 Apr;12(4):218-25. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vitro
Chemical Information
Reinheit & Dokumentation
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SW208108