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GBT 440 

Cat. No.: HY-18681 Purity: 99.46%
Data Sheet SDS Handling Instructions

GBT 440 is a modulator of sickle hemoglobin (HbS), extracted from patent WO2015116061A1, compound 5, which can be used in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

For research use only. We do not sell to patients.
GBT 440 Chemical Structure

GBT 440 Chemical Structure

CAS No. : 1446321-46-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO $385 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

GBT 440 is a modulator of sickle hemoglobin (HbS), extracted from patent WO2015116061A1, compound 5, which can be used in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02497924 Global Blood Therapeutics Anemia, Sickle Cell June 2015 Phase 1
NCT02567695 Global Blood Therapeutics Sickle Cell Disease September 2015 Phase 1
NCT02850406 Global Blood Therapeutics Sickle Cell Disease May 2016 Phase 2
NCT02285088 Global Blood Therapeutics Healthy Subjects|Sickle Cell Disease December 2014 Phase 1
NCT02567682 Global Blood Therapeutics Sickle Cell Disease September 2015 Phase 1
NCT03041909 Global Blood Therapeutics Sickle Cell Disease August 2016 Phase 2
NCT02989168 Global Blood Therapeutics Idiopathic Pulmonary Fibrosis November 2016 Phase 2
NCT03161015 Global Blood Therapeutics Renal Impairment November 2016 Phase 1
NCT03114540 Global Blood Therapeutics Hepatic Impairment March 17, 2017 Phase 1
NCT02846324 Global Blood Therapeutics Idiopathic Pulmonary Fibrosis June 2016 Phase 2
NCT03036813 Global Blood Therapeutics Sickle Cell Disease December 2016 Phase 3
NCT03051711 Global Blood Therapeutics|Mayo Clinic Cardio-pulmonary Function December 2016 Phase 1
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.9641 mL 14.8205 mL 29.6410 mL
5 mM 0.5928 mL 2.9641 mL 5.9282 mL
10 mM 0.2964 mL 1.4821 mL 2.9641 mL
References
Molecular Weight

337.37

Formula

C₁₉H₁₉N₃O₃

CAS No.

1446321-46-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.46%

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Product Name:
GBT 440
Cat. No.:
HY-18681
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