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NAT8 - N-acetyltransferase 8 (putative) Gene

Also Known as GLA; CML1; CCNAT; Hcml1; ATase2; TSC501; TSC510

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9027

About NAT8

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:73,640,723-73,642,422 (from NCBI)

This gene has 1 transcript (splice variant), 344 orthologues and 3 paralogues. Restricted expression toward kidney (RPKM 344.5).

Summary

This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008]

NAT8 Products (1)

mRNA	Protein	Name
NM_003960.4	NP_003951.3	N-acetyltransferase 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-S-conjugate N-acetyltransferase activity	IDA IDA: Inferred from direct assay	20392701	GOA
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	IDA IDA: Inferred from direct assay	19011241	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19011241	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in peptidyl-lysine N6-acetylation	IDA IDA: Inferred from direct assay	19011241	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19011241	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	20392701	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	24556617	GOA
located in endoplasmic reticulum-Golgi intermediate compartment membrane	IDA IDA: Inferred from direct assay	19011241	GOA
located in membrane	IDA IDA: Inferred from direct assay	20392701	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAT8 Protein Structure

Acetyltransf_1

0
100
200
227 a.a.

Protein Preferred Names	Protein Names
N-acetyltransferase 8	N-acetyltransferase 8 (GCN5-related, putative)

NAT8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NAT8	Q9UHE5	REEP2	Homo sapiens	Q9BRK0	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	REEP2	Homo sapiens	Q9BRK0	Y2H Array	32296183
Intra	NAT8	Q9UHE5	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	NAT8	Q9UHE5	ATP6V0E1	Homo sapiens	O15342	Y2H Array	32296183
Intra	NAT8	Q9UHE5	ATP6V0E1	Homo sapiens	O15342	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	NAT8	Q9UHE5	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	TMEM143	Homo sapiens	Q96AN5	Y2H Array	32296183
Intra	NAT8	Q9UHE5	TMEM143	Homo sapiens	Q96AN5	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	NAT8	Q9UHE5	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Array	32296183
Intra	NAT8	Q9UHE5	TSPAN31	Homo sapiens	Q12999	Y2H Array	32296183
Intra	NAT8	Q9UHE5	TSPAN31	Homo sapiens	Q12999	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	NAT8	Q9UHE5	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	NAT8	Q9UHE5	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	NAT8	Q9UHE5	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	NAT8	Q9UHE5	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	NAT8	Q9UHE5	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	NAT8	Q9UHE5	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	NAT8	Q9UHE5	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	NAT8	Q9UHE5	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	NAT8	Q9UHE5	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	JPH1	Homo sapiens	Q9HDC5	Y2H Array	32296183
Intra	NAT8	Q9UHE5	JPH1	Homo sapiens	Q9HDC5	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	NAT8	Q9UHE5	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	NAT8	Q9UHE5	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	NAT8	Q9UHE5	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183
Intra	NAT8	Q9UHE5	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	YIPF4	Homo sapiens	Q9BSR8	Y2H Array	32296183
Intra	NAT8	Q9UHE5	YIPF4	Homo sapiens	Q9BSR8	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	NAT8	Q9UHE5	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	NAT8	Q9UHE5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	NAT8	Q9UHE5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Iminoglycinuria	Iminoglycinuria, Digenic IG

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09044	NAT8L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181719	NAT8L-IN-1	Inhibitor	/	Unkown
HY-181750	NAT8L-IN-2		/	Unkown
HY-RS09043	NAT8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22671	Nat8l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29185	Nat8l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NAT8	MGD	MGI:1915646
Rattus norvegicus	NAT8	RGD	RGD:621609