OS9 - OS9 endoplasmic reticulum lectin Gene

Also Known as OS-9; ERLEC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10956

About OS9

Cytogenetic location: 12q13.3-q14.1 Genomic coordinates (GRCh38): 12:57,694,132-57,721,557 (from NCBI)

This gene has 37 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 82.8), thyroid (RPKM 81.3) and 25 other tissues.

Summary

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

OS9 Products (11)

mRNA Protein Name
NM_001017956.3 NP_001017956.1 protein OS-9 isoform 2 precursor
NM_001017957.3 NP_001017957.1 protein OS-9 isoform 3 precursor
NM_001017958.3 NP_001017958.1 protein OS-9 isoform 4 precursor
NM_001261420.2 NP_001248349.1 protein OS-9 isoform 5 precursor
NM_001261421.2 NP_001248350.1 protein OS-9 isoform 6 precursor
NM_001261422.2 NP_001248351.1 protein OS-9 isoform 7 precursor
NM_001261423.2 NP_001248352.1 protein OS-9 isoform 8 precursor
NM_001410978.1 NP_001397907.1 protein OS-9 isoform 9 precursor
NM_001410979.1 NP_001397908.1 protein OS-9 isoform 10 precursor
NM_001410980.1 NP_001397909.1 protein OS-9 isoform 11 precursor
NM_006812.4 NP_006803.1 protein OS-9 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IDA
IDA: Inferred from direct assay
18264092 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15721254 GOA
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
18264092 GOA
involved in negative regulation of retrograde protein transport, ER to cytosol IMP
IMP: Inferred from mutant phenotype
25660456 GOA
involved in protein retention in ER lumen IDA
IDA: Inferred from direct assay
18417469 GOA
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
19084021 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
19084021 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19084021 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
18264092 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OS9 Protein Structure

PRKCSH

PRKCSH: Glucosidase II beta subunit-like protein (110 - 181)

  • 0
  • 200
  • 400
  • 600
  • 667 a.a.
Protein Preferred Names Protein Names

protein OS-9

  • amplified in osteosarcoma 9

OS9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OS9 Q13438 EGLN1 Homo sapiens Q9GZT9
Anti Tag CoIP
15721254
Intra
OS9 Q13438 ERN1 Homo sapiens O75460-1
Anti Tag CoIP
26551274
Intra
OS9 Q13438 NXPE3 Homo sapiens Q969Y0
Anti Tag CoIP
33961781
Intra
OS9 Q13438 SEL1L Homo sapiens Q9UBV2
Pull Down
22119785
Intra
OS9 Q13438 SEL1L Homo sapiens Q9UBV2
Anti Tag CoIP
26551274
Intra
OS9 Q13438 SEL1L Homo sapiens Q9UBV2
Anti Tag CoIP
33961781
Intra
OS9 Q13438 HIF1A Homo sapiens Q16665
Anti Tag CoIP
15721254
Intra
OS9 Q13438 HIF1A Homo sapiens Q16665
Pull Down
15721254
Cross: Cross-species interaction Intra: Intraspecies interaction

OS9 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82194 OS9 Antibody (YA1939) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

  • Familial Encephalopathy With Neuroserpin Inclusion Bodies

  • FENIB

  • Encephalopathy, Familial, With Collins Bodies

  • Familial Dementia With Neuroserpin Inclusion Bodies

  • Familial Encephalopathy With Collins Bodies
Erythrocytosis, Familial, 3

  • ECYT3

  • Familial Erythrocytosis 3

  • Erythrocytosis, Familial, Type 3
Erythrocytosis, Familial, 5

  • ECYT5

  • Familial Erythrocytosis 5
Fibrosarcomatous Osteosarcoma

  • Fibroblastic Osteosarcoma

  • Fibrosarcomatous Osteogenic Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09834 OS9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus OS9 VGNC VGNC:63975
Macaca mulatta OS9 VGNC VGNC:75635
Bos taurus OS9 VGNC VGNC:32455
Mus musculus OS9 MGD MGI:1924301
Rattus norvegicus OS9 RGD RGD:1359574
Canis familiaris OS9 VGNC VGNC:44148
Others OS9 NCBI