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SEL1L - SEL1L adaptor subunit of ERAD E3 ubiquitin ligase Gene

Also Known as Hrd3; SEL1L1; PRO1063; SEL1-LIKE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6400

About SEL1L

Cytogenetic location: 14q31.1 Genomic coordinates (GRCh38): 14:81,471,547-81,533,853 (from NCBI)

This gene has 6 transcripts (splice variants), 214 orthologues and 4 paralogues. Ubiquitous expression in pancreas (RPKM 48.9), thyroid (RPKM 38.9) and 25 other tissues.

Summary

The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the Proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SEL1L Products (2)

mRNA	Protein	Name
NM_001244984.2	NP_001231913.1	protein sel-1 homolog 1 isoform 2 precursor
NM_005065.6	NP_005056.3	protein sel-1 homolog 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18264092	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	21454652	GOA
involved in retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Derlin-1 retrotranslocation complex	IDA IDA: Inferred from direct assay	21454652	GOA
part of Hrd1p ubiquitin ligase ERAD-L complex	IMP IMP: Inferred from mutant phenotype	26471130	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	26471130	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEL1L Protein Structure

fn2

Sel1

0
200
400
600
794 a.a.

Protein Preferred Names	Protein Names
protein sel-1 homolog 1	SEL1L, ERAD E3 ligase adaptor subunit

SEL1L Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SEL1L	Q9UBV2	FOXRED2	Homo sapiens	Q8IWF2	Anti Bait CoIP	19706418
Intra	SEL1L	Q9UBV2	OS9	Homo sapiens	Q13438	Anti Tag CoIP	18711132
Intra	SEL1L	Q9UBV2	OS9	Homo sapiens	Q13438	Anti Bait CoIP	28827405
Intra	SEL1L	Q9UBV2	OS9	Homo sapiens	Q13438	Pull Down	22119785
Intra	SEL1L	Q9UBV2	OS9	Homo sapiens	Q13438	Anti Bait CoIP	29496332
Intra	SEL1L	Q9UBV2	SYVN1	Homo sapiens	Q86TM6	Pull Down	22119785
Intra	SEL1L	Q9UBV2	SYVN1	Homo sapiens	Q86TM6	Anti Bait CoIP	28827405

Cross: Cross-species interaction Intra: Intraspecies interaction

SEL1L Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811260	Sel-1L Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Type 1 Diabetes Mellitus 11	Diabetes Mellitus, Insulin-Dependent, 11 Iddm11 Insulin-Dependent Diabetes Mellitus 11 T1D11 Insulin-Dependent Diabetes Mellitus-11
Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
Lipase Deficiency, Combined	Lipoprotein Lipase Deficiency With Hepatic Triglyceride Lipase Deficiency Lpl And Htgl Deficiency Lpl And Hl Deficiency Familial Lipase Maturation Factor 1 Deficiency Lipase Deficiency Combined Combined Lipase Deficiency Familial Lmf1 Deficiency CLD
Type 1 Diabetes Mellitus 10	Diabetes Mellitus, Insulin-Dependent, 10 IDDM10 Insulin-Dependent Diabetes Mellitus 10 Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10 T1D10 Diabetes, Mellitus, Insulin-Dependent 10 Diabetes Mellitus, Insulin-Dependent, Type 10
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12630	SEL1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12631	SEL1L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22799	Sel1l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SEL1L	VGNC	VGNC:77155
Rattus norvegicus	SEL1L	RGD	RGD:620147
Mus musculus	SEL1L	MGD	MGI:1329016
Felis catus	SEL1L	VGNC	VGNC:64978
Canis familiaris	SEL1L	VGNC	VGNC:54990
Bos taurus	SEL1L	VGNC	VGNC:49962
Others	SEL1L	NCBI