Sel-1L Antibody
(Synonyms: TSA305, UNQ128/PRO1063, SEL1L, Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L)Sel-1L Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Sel-1L.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
Sel-1L Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Sel-1L.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 102 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 33; 88 kDa
Purified recombinant protein of human Sel-1L
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Sel-1L plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling[1][2][3][4].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Highly expressed in pancreas. -
Isoforms & Post-Translational Modification
Sel-1L has 2 isoforms, Q9UBV2-1: amino acid length is 794, molecular weight is 88755 Da (predicted); Q9UBV2-2: amino acid length is 301, molecular weight is 33530 Da (predicted).N-glycosylated
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Subunit
Homodimer and homooligomer (By similarity).
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SwissProt ID
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Synonyms
TSA305, UNQ128/PRO1063, SEL1L, Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L
Documentation
References
[1]. Lilley BN, et al. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14296-301. [Content Brief]
[2]. Nguyen CC, et al. Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO. J Virol. 2018 Sep 15;92(18):. [Content Brief]
[3]. Wang HH, et al. Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders. J Clin Invest. 2024 Jan 16;134(2):. [Content Brief]
[4]. Weis D, et al. Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death. J Clin Invest. 2024 Jan 16;134(2):. [Content Brief]
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