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VKORC1L1 - vitamin K epoxide reductase complex subunit 1 like 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 154807

About VKORC1L1

Cytogenetic location: 7q11.21 Genomic coordinates (GRCh38): 7:65,865,772-65,959,558 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 25.2), lung (RPKM 7.7) and 23 other tissues.

Summary

This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]

VKORC1L1 Products (2)

mRNA	Protein	Name
NM_001284342.3	NP_001271271.1	vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 2
NM_173517.6	NP_775788.2	vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	EXP EXP: Inferred from Experiment	21367861	GOA
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IDA IDA: Inferred from direct assay	21367861	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	21367861	GOA
involved in peptidyl-glutamic acid carboxylation	IMP IMP: Inferred from mutant phenotype	24532791	GOA
involved in vitamin K metabolic process	IDA IDA: Inferred from direct assay	21367861	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21367861	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VKORC1L1 Protein Structure

VKOR

0
100
176 a.a.

Protein Preferred Names	Protein Names
vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1-like protein 1

VKORC1L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VKORC1L1	Q8N0U8	KLKB1	Homo sapiens	P03952	Y2H Pooling	32814053
Intra	VKORC1L1	Q8N0U8	KLKB1	Homo sapiens	P03952	Validated Y2H	32814053
Intra	VKORC1L1	Q8N0U8	KLKB1	Homo sapiens	P03952	Y2H Array	32814053
Intra	VKORC1L1	Q8N0U8	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	VHL	Homo sapiens	P40337-2	Validated Y2H	32814053
Intra	VKORC1L1	Q8N0U8	VHL	Homo sapiens	P40337-2	Y2H Pooling	32814053
Intra	VKORC1L1	Q8N0U8	VHL	Homo sapiens	P40337-2	Y2H Array	32814053
Intra	VKORC1L1	Q8N0U8	PCYT1B	Homo sapiens	Q9Y5K3-3	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	PCYT1B	Homo sapiens	Q9Y5K3-3	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	PCYT1B	Homo sapiens	Q9Y5K3-3	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	PCYT1A	Homo sapiens	P49585	Anti Tag CoIP	33961781
Intra	VKORC1L1	Q8N0U8	PCYT1A	Homo sapiens	P49585	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	PCYT1A	Homo sapiens	P49585	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	CCT2	Homo sapiens	P78371	Y2H Array	32814053
Intra	VKORC1L1	Q8N0U8	CCT2	Homo sapiens	P78371	Y2H Pooling	32814053
Intra	VKORC1L1	Q8N0U8	CCT2	Homo sapiens	P78371	Validated Y2H	32814053
Intra	VKORC1L1	Q8N0U8	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	VKORC1L1	Q8N0U8	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	LPL	Homo sapiens	P06858	Y2H Array	32814053
Intra	VKORC1L1	Q8N0U8	LPL	Homo sapiens	P06858	Y2H Pooling	32814053
Intra	VKORC1L1	Q8N0U8	LPL	Homo sapiens	P06858	Validated Y2H	32814053
Intra	VKORC1L1	Q8N0U8	AGT	Homo sapiens	P01019	Validated Y2H	32814053
Intra	VKORC1L1	Q8N0U8	AGT	Homo sapiens	P01019	Y2H Pooling	32814053
Intra	VKORC1L1	Q8N0U8	AGT	Homo sapiens	P01019	Y2H Array	32814053
Intra	VKORC1L1	Q8N0U8	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	VKORC1L1	Q8N0U8	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	VKORC1L1	Q8N0U8	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES
Hereditary Combined Deficiency Of Vitamin K-Dependent Clotting Factors	Hereditary Combined Deficiency Of Factors Ii, Vii, Ix And X Vkcfd
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 2	VKCFD2 Combined Deficiency Of Vitamin K-Dependent Clotting Factors 2 Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15660	VKORC1L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VKORC1L1	MGD	MGI:1916818
Canis familiaris	VKORC1L1	VGNC	VGNC:82304
Rattus norvegicus	VKORC1L1	RGD	RGD:1303249
Bos taurus	VKORC1L1	VGNC	VGNC:58426
Macaca mulatta	VKORC1L1	VGNC	VGNC:79322
Others	VKORC1L1	NCBI