AGT - angiotensinogen Gene

Also Known as ANHU; hFLT1; SERPINA8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 183

About AGT

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:230,702,523-230,745,583 (from NCBI)

This gene has 13 transcripts (splice variants), 194 orthologues, 36 paralogues and is associated with 5 phenotypes. Biased expression in liver (RPKM 264.6), brain (RPKM 76.5) and 3 other tissues.

Summary

The protein encoded by this gene, pre-angiotensinogen or Angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme Renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019]

AGT Products (2)

mRNA	Protein	Name
NM_001382817.3	NP_001369746.2	angiotensinogen precursor
NM_001384479.1	NP_001371408.1	angiotensinogen precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables hormone activity	IDA IDA: Inferred from direct assay	1567413	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10969042	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	24296617	GOA
enables sodium channel regulator activity	IMP IMP: Inferred from mutant phenotype	15803439	GOA
enables type 1 angiotensin receptor binding	IPI IPI: Inferred from physical interaction	1378723	GOA
enables type 2 angiotensin receptor binding	IPI IPI: Inferred from physical interaction	10406457	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10406457	GOA
involved in angiotensin-activated signaling pathway	IDA IDA: Inferred from direct assay	1567413	GOA
involved in angiotensin-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	15153556	GOA
involved in kidney development	IMP IMP: Inferred from mutant phenotype	16116425	GOA
involved in maintenance of blood vessel diameter homeostasis by renin-angiotensin	IDA IDA: Inferred from direct assay	1567413	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	28283184	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	24296617	GOA
involved in negative regulation of neurotrophin TRK receptor signaling pathway	IDA IDA: Inferred from direct assay	10406457	GOA
involved in positive regulation of CoA-transferase activity	IDA IDA: Inferred from direct assay	18971559	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15153556	GOA
involved in positive regulation of branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	18607644	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	15652490	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15652490	GOA
acts upstream of positive regulation of extracellular matrix assembly	IDA IDA: Inferred from direct assay	30729664	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10406457	GOA
involved in positive regulation of gap junction assembly	IGI IGI: Inferred from genetic interaction	17416596	GOA
involved in positive regulation of macrophage derived foam cell differentiation	IDA IDA: Inferred from direct assay	18971559	GOA
involved in positive regulation of membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	15803439	GOA
acts upstream of positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	30729664	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15652490	GOA
involved in positive regulation of protein metabolic process	IDA IDA: Inferred from direct assay	18971559	GOA
involved in regulation of blood pressure	IGI IGI: Inferred from genetic interaction	17416596	GOA
involved in regulation of cardiac conduction	IGI IGI: Inferred from genetic interaction	17416596	GOA
involved in regulation of extracellular matrix assembly	IGI IGI: Inferred from genetic interaction	17416596	GOA
involved in renal system process	IDA IDA: Inferred from direct assay	21183621	GOA
acts upstream of response to angiotensin	IDA IDA: Inferred from direct assay	30729664	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	4300938	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	18971559	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGT Protein Structure

Serpin

0
100
200
300
400
485 a.a.

Protein Preferred Names	Protein Names
angiotensinogen	alpha-1 antiproteinase, antitrypsin

AGT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AGT	P01019	SNX12	Homo sapiens	Q9UMY4	Validated Y2H	32814053
Intra	AGT	P01019	SNX12	Homo sapiens	Q9UMY4	Y2H Array	32814053
Intra	AGT	P01019	SNX12	Homo sapiens	Q9UMY4	Y2H Pooling	32814053
Intra	AGT	P01019	TMEM185A	Homo sapiens	Q8NFB2	Validated Y2H	32814053
Intra	AGT	P01019	TMEM185A	Homo sapiens	Q8NFB2	Y2H Array	32814053
Intra	AGT	P01019	TMEM185A	Homo sapiens	Q8NFB2	Y2H Pooling	32814053
Intra	AGT	P01019	EIF2B4	Homo sapiens	Q9UI10	Y2H Array	32814053
Intra	AGT	P01019	EIF2B4	Homo sapiens	Q9UI10	Y2H Pooling	32814053
Intra	AGT	P01019	EIF2B4	Homo sapiens	Q9UI10	Validated Y2H	32814053
Intra	AGT	P01019	NPHP1	Homo sapiens	C9J082	Y2H Pooling	32814053
Intra	AGT	P01019	NPHP1	Homo sapiens	C9J082	Validated Y2H	32814053
Intra	AGT	P01019	NPHP1	Homo sapiens	C9J082	Y2H Array	32814053
Intra	AGT	P01019	TGOLN2	Homo sapiens	O43493-5	Validated Y2H	32814053
Intra	AGT	P01019	TGOLN2	Homo sapiens	O43493-5	Y2H Pooling	32814053
Intra	AGT	P01019	TGOLN2	Homo sapiens	O43493-5	Y2H Array	32814053
Intra	AGT	P01019	SLFN12	Homo sapiens	Q8IYM2	Y2H Pooling	32814053
Intra	AGT	P01019	SLFN12	Homo sapiens	Q8IYM2	Validated Y2H	32814053
Intra	AGT	P01019	SLFN12	Homo sapiens	Q8IYM2	Y2H Array	32814053
Intra	AGT	P01019	PRMT5	Homo sapiens	O14744	Y2H Array	32814053
Intra	AGT	P01019	PRMT5	Homo sapiens	O14744	Validated Y2H	32814053
Intra	AGT	P01019	PRMT5	Homo sapiens	O14744	Y2H Pooling	32814053
Intra	AGT	P01019	NME4	Homo sapiens	O00746	Y2H Pooling	32814053
Intra	AGT	P01019	NME4	Homo sapiens	O00746	Validated Y2H	32814053
Intra	AGT	P01019	NME4	Homo sapiens	O00746	Y2H Array	32814053
Cross	AGT	P01019	Agtr1	Rattus norvegicus	P25095	Saturation Binding	18202720

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AGT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72477	Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution)	AAH11519.1 (D34-A485)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73653	Serpin A8/Angiotensinogen Protein, Human (HEK293, His)	NP_000020.1 (D34-A485)	≥ 95%, as determined by reducing SDS-PAGE.

AGT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83896	AGT Antibody (YA3593)	WB, ELISA	Human
HY-P83896A	AGT Antibody (YA3593)(PBS only)	WB, ELISA	Human
HY-P89537	Angiotensin I Antibody (YA8881)	ELISA	human

Related Diseases

Diseases	Alias
Renal Tubular Dysgenesis	Primitive Renal Tubule Syndrome RTD Renal Tubular Dysgenesis Of Genetic Origin Allanson Pantzar Mcleod Syndrome Renotubular Dysgenesis Dysgenesis, Renal Tubular Primitive Kidney Tubule Syndrome
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Anuria	Suppression Of Urinary Secretion
Atrial Fibrillation	A-Fib Fibrillation, Atrial Af - [Atrial Fibrillation] Rapid Atrial Fibrillation A Fib - [Atrial Fibrillation]
Renal Fibrosis
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Oligohydramnios	Oligohydramnios - Delivered Antepartum Oligohydramnios Delivered Oligohydramnios Oligohydramnios, Antepartum Condition Or Complication Deficient Liquor Oligohydramnios, Unspecified Trimester Reduced Liquor Volume
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Fibromuscular Dysplasia
Obstructive Nephropathy	Con Congenital Obstructive Nephropathy Nephropathy Obstructive
Vesicoureteral Reflux	Vesico-Ureteral Reflux
Gitelman Syndrome	Familial Hypokalemia-Hypomagnesemia Hypomagnesemia-Hypokalemia, Primary Renotubular, With Hypocalciuria Potassium And Magnesium Depletion GTLMNS Gitelman'S Syndrome Gs Hypokalemia-Hypomagnesemia, Primary Renotubular, With Hypocalciuria Tubular Hypomagnesemia-Hypokalemia With Hypocalcuria Bartter Syndrome Gitelman Variant Bartter Syndrome Hypocalciuric Variant Primary Renotubular Hypomagnesemia-Hypokalemia With Hypocalciuria
Potter'S Syndrome	Potter Sequence Potter Syndrome Oligohydramnios Sequence Congenital Absence Of Kidneys Syndrome
Sick Sinus Syndrome	Sinus Node Dysfunction Sinus Node Disease Sinus Node Infection Snd Sss Snd - [Sinus Node Dysfunction] Sinoatrial Node Dysfunction Sss - [Sick Sinus Syndrome] Sick Sinus Sick Sinus Tachycardia
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
Multicystic Dysplastic Kidney	Multicystic Renal Dysplasia Multicystic Kidney Dysplasia Mcdk Multiple Congenital Cysts Of Kidney Developmental Multicystic Kidney
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Cerebrovascular Disease	Cerebrovascular Disorder Cerebrovascular Accident Cerebrovascular Disorders Cva Stroke
Eclampsia	Eclampsia In Puerperium Postpartum Eclampsia Eclampsia, Postpartum Puerperal Eclampsia
Otosclerosis	Otospongiosis
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Sleep Apnea	Sleep Apnea Syndromes
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Apnea, Obstructive Sleep	Obstructive Sleep Apnea Syndrome Obstructive Sleep Apnea Sleep Apnea, Obstructive Osa Osas Sleep Apnea/Hypopnea Syndrome Sahs Upper Airway Resistance Sleep Apnea Syndrome Apnea, Obstructive Obstructive Apnea Osahs Sleep Apnea Hypopnea Syndrome Sleep Apnea Syndrome, Obstructive Sleep Apnea Obstructive Sleep Apnea Syndromes Obstructive Sleep Apnoea Syndrome Obstructive Sleep Apnoea, Adult Osa - [Obstructive Sleep Apnoea] Obstructive Sleep Apnoea, Paediatric Obstructive Sleep Apnoea Hypopnoea Syndrome Osa Syndrome Sleep Apnoea Nos [Sas] - Sleep Apnoea Syndrome Sleep Apnoea Syndrome [Osahs] - Obstructive Sleep Apnoea-Hypopnea Syndrome [Sahs] - Sleep Apnoea-Hypopnea Syndrome
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Pulmonary Edema
Iga Glomerulonephritis	Iga Nephropathy Glomerulonephritis, Iga Berger'S Iga Or Igg Nephropathy Focal Glomerulonephritis Primary Iga Nephropathy Segmental Glomerulonephritis Berger Disease Berger'S Disease Igan Nephritis, Iga Type Nephropathy Iga Glomerulonephritis Focal Iga Nephropathy, Susceptibility To Primary Immunoglobulin A Nephropathy
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Renal Hypertension	Hypertension Renal Hypertension, Renal
Renovascular Hypertension	Hypertension, Renovascular Hypertension Renovascular
Fabry Disease	Alpha-Galactosidase A Deficiency Anderson-Fabry Disease Angiokeratoma Corporis Diffusum Ceramide Trihexosidase Deficiency Fabry Disease, Cardiac Variant Fabry'S Disease Hereditary Dystopic Lipidosis Gla Deficiency FD Alpha Galactosidase Deficiency Deficiency Of Melibiase Angiokeratoma, Diffuse Angiokeratoma Diffuse Diffuse Angiokeratoma
Renal Artery Disease	Renal Vascular Disease Vascular Disorder Of Kidney Renal Vascular Disorder
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Microvascular Complications Of Diabetes 1	Proliferative Diabetic Retinopathy Microvascular Complications Of Diabetes, Susceptibility To, 1 MVCD1 Diabetic Nephropathy Non-Proliferative Diabetic Retinopathy Nonproliferative Diabetic Retinopathy Proliferative Retinopathy, Diabetic Proliferative Retinopathy, Diabetic, Susceptibility To Nonproliferative Retinopathy, Diabetic Nonproliferative Retinopathy, Diabetic, Susceptibility To Pdr Diabetic End-Stage Renal Disease Diabetic Neuropathy Diabetic Neuropathies Complications Of Diabetes Mellitus Diabetes Mellitus, Independent Of Type With Proliferative Retinopathy
Conn'S Syndrome	Cushing Syndrome Hyperaldosteronism Primary Hyperaldosteronism Hypercortisolism Primary Aldosteronism Cushing'S Syndrome Adrenal Gland Hyperfunction Conn Syndrome Hyperadrenalism Ectopic Acth Syndrome Hyperadrenocorticism Cushing Disease Cushing'S Disease Adrenal Cortex Adenoma Corticotroph Pituitary Adenoma Pituitary Corticotroph Micro-Adenoma Pituitary-Dependent Cushing Syndrome Pituitary Acth Hypersecretion Acth Syndrome, Ectopic Acth-Secreting Pituitary Adenoma Adrenal Hyperfunction Resulting From Pituitary Acth Excess Ectopic Adrenocorticotropic Hormone Syndrome Nodular Primary Adrenocortical Dysplasia Pituitary Dependent Cushing Syndrome Pituitary Cushing Syndrome Pituitary-Dependant Cushing Syndrome Pituitary-Dependant Hypercortisolism Pituitary-Dependant Hypercortisolism Disorder Aldosteronism Primary Acth Syndrome Ectopic Adrenal Cushing'S Syndrome Adrenal Cortical Adenoma Cushing Syndrome Nos Cortisol Hypersecretion Corticoadrenal Hypersecretion Cushing Syndrome Secondary To Ectopic Acth-Secretion Ectopic Cushing Syndrome Hypercortisolism Due To Nonpituitary Tumour Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome Idiopathic Aldosteronism Aldosteronism Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia Primary Aldosteronism Due To Adrenal Hyperplasia
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Hyperaldosteronism, Familial, Type I	Glucocorticoid-Remediable Aldosteronism Gra Familial Hyperaldosteronism Type 1 Hyperaldosteronism, Familial Type 1 HALD1 Fh I Glucocorticoid-Suppressible Hyperaldosteronism Gsh Acth-Dependent Hyperaldosteronism Syndrome Aldosteronism, Glucocorticoid-Remediable Dexamethasone Sensitive Hypertension Glucocorticoid Sensitive Hypertension Familial Hyperaldosteronism Type I Fh1 Aldosteronism, Sensitive To Dexamethasone Dexamethasone-Sensitive Hypertension Fh-I Glucocorticoid-Sensitive Hypertension Hyperaldosteronism, Familial, 1 Aldosteronism Sensitive To Dexamethasone Familial Hyperaldosteronism 1 Fh Type 1 Familial Aldosteronism Type I
Diabetes Mellitus	Diabetes
Microvascular Complications Of Diabetes 5	Diabetic Retinopathy Microvascular Complications Of Diabetes, Susceptibility To, 5 MVCD5 Retinopathy, Diabetic Diabetic Nephropathy Retinopathy, Diabetic, Susceptibility To Retinal Abnormality - Diabetes-Related
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Liddle Syndrome 1	Liddle Syndrome Pseudoaldosteronism Liddle'S Syndrome LIDLS1 Lidls Pseudohyperaldosteronism Pseudoprimary Hyperaldosteronism Pseudohyperaldosteronism Type 1 Liddles Syndrome
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Plantar Fascial Fibromatosis	Dupuytren'S Contracture Of Foot Ledderhose'S Disease Fibromatosis, Plantar Ledderhose Disease
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Aortic Valve Disease 2	Aortic Valve Stenosis Aortic Stenosis Rheumatic Aortic Stenosis AOVD2 Bicuspid Aortic Valve Rheumatic Aortic Valve Stenosis Valvular Aortic Stenosis Aortic Valve Disease, Type 2 Aortic Valve Stricture Aortic Valve Obstruction Obstructed Aorta Valve Rheumatic Aortic Obstruction Rheumatic Aortic Valve Obstruction Rheumatic Aortic Stricture Aortic Valve Regurgitation Aortic Insufficiency With Stenosis Rheumatic Aortic Valve Stenosis With Insufficiency Rheumatic Aortic Stenosis With Incompetence Rheumatic Aortic Stenosis With Regurgitation
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Malignant Secondary Hypertension
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

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Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108764	Mipomersen sodium	Inhibitor	95.60%	Phase 3
HY-W002585	O6-Benzylguanine		99.92%	Phase 3
HY-143230	Custirsen	Inducer	96.12%	Phase 3
HY-145649A	Zilebesiran sodium		/	Phase 2

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99530	Valanafusp alfa		98.42%	Phase 2
HY-P992048	AGT-182	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150738	ODN 2088	Antagonist	98.82%	Unkown
HY-148413	Aprinocarsen sodium	Inhibitor	98.42%	Unkown
HY-150736	ODN 20844	Inhibitor	96.14%	Unkown
HY-145649	Zilebesiran		95.63%	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-106435	Cystemustine	Inhibitor	/	Unkown
HY-147406	Tonlamarsen		/	Unkown
HY-150740	ODN 21595	Inhibitor	/	Unkown
HY-186228	Anticancer agent 333		/	Unkown
HY-D2935	CoDi2		/	Unkown
HY-D2981	CoDi1		/	Unkown
HY-D2995	CoDi3		/	Unkown
HY-P5939	Angiotensinogen (1-13) (human)		/	Unkown
HY-RS00466	AGT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00473	AGXT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08412	Mgmt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-19932	MK-2748	Inhibitor	/	Unkown
HY-RS17726	Agt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24191	Agt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AGT	VGNC	VGNC:69751
Bos taurus	AGT	VGNC	VGNC:103718
Rattus norvegicus	AGT	RGD	RGD:2069
Canis familiaris	AGT	VGNC	VGNC:37718
Mus musculus	AGT	MGD	MGI:87963
Others	AGT	NCBI