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Cat. No.: HY-186228

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Anticancer agent 333

Anticancer agent 333 is a tetrazinone anticancer agent with broad-spectrum anticancer activity, targeting MGMT/AGT-deficient cancer cells (IC₅₀≤20 μM). Anticancer agent 333 exhibits favorable safety profiles in rat and canine animal models. Anticancer agent 333 can be used for the research of MGMT-deficient cancers and related tumors.

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CAS No.: 3075414-82-0
화학식: C₈H₇F₃N₆O₃
분자량:292.17

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 333 Chemical Structure

CAS No.: 3075414-82-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

MGMT

All DNA Methyltransferase Isoforms :

In Vitro

Anticancer agent 333 (I-1) weakly inhibits viability of MGMT positive / MMR positive and MGMT positive / MMR negative LN229 glioblastoma cells, with an IC₅₀ greater than 100 μM for both cell lines^[1].
Anticancer agent 333 (I-1) exhibits broad anti-cancer activity across diverse human cancer cell lines, with the highest potency (EC₅₀/IC₅₀ ≤ 30 μM) in most lymphoma, small cell lung carcinoma, colon carcinoma, melanoma, and glioblastoma cell lines tested^[1].
Anticancer agent 333 (I-1) (66.7 μM; 5 days) exhibits lineage-dependent anti-cancer activity across 885 human cancer cell lines, with the most potent effects (Log2 fold change -3.5 to -2.0) observed in a subset of tested cell lines when treated at 66.7 μM for 5 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

885 barcoded human cancer cell lines across over 45 lineages
Concentration:

66.7 μM; 8-point 3-fold dilution dose range
Incubation Time:

5 days
Result:

Caused log2 fold change -3.5 to -2.0 (highly significant anti-cancer effect) in a subset of cell lines.
Caused log2 fold change >-2.0 to -1.0 (significant anti-cancer effect) in a subset of cell lines.
Caused log2 fold change >-1.0 to -0.5 (moderate anti-cancer effect) in a subset of cell lines including KYSE510, LS180, HOS, ASPC1, and others.
Caused log2 fold change >-0.5 to -0.001 (weak anti-cancer effect) in a subset of cell lines including RD, NCI-H1563, MONOMAC6, and others.
Showed no detectable anti-cancer effect in a subset of cell lines.

Chemical Information

CAS No. 3075414-82-0
분자량 292.17
화학식 C₈H₇F₃N₆O₃
SMILES

O=C(C(N=CN12)=C2N=NN(CCOC(F)(F)F)C1=O)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1].
Kyle Thomas, et al. Fluoroalkoxyalkylene-dihydroimidazo[5,1-d]tetrazinone compounds and related compounds and their use in treating medical conditions. WO2025034537A1. 2024-08-02.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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Anticancer agent 333

All DNA Methyltransferase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Anticancer agent 333 Related Classifications

HY-186228 Related Classifications