Tonlamarsen  (Synonyms: ION-904)

Tonlamarsen (ION-904) is a GalNAc-conjugated antisense oligonucleotide and Angiotensinogen synthesis inhibitor. Tonlamarsen specifically reduces the production of Angiotensinogen in the liver and plasma, and exhibits extremely low activity in the kidneys. Tonlamarsen can be used in research related to hypertension and heart failure^[1].

Angiotensinogen^[1]

Tonlamarsen significantly reduces plasma AGT levels in subjects, while showing no signals of hyperkalemia, renal dysfunction, hypotension, liver dysfunction or thrombocytopenia (off-target effects)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7021.13

C₂₄₁H₃₄₉N⁶⁵O₁₂P₁₆S₁₂

2589926-20-3

DNA, d([2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rG-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]m5C-T-sp-G-sp-A-sp-T-sp-T-sp-T-sp-G-sp-T-sp-m5C-sp-m5C-sp-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-sp-[2′-O-(2-methoxyethyl)]rG), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate]

[Tonlamarsen]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Morgan E, et al. Effect of ION904, an Antisense Inhibitor of Angiotensinogen Production: Results of Phase 1 and Phase 2 Pilot Studies[J]. Circulation, 2023, 148(Suppl_1): A17395-A17395.