Tonlamarsen
Tonlamarsen (ION-904) is a GalNAc-conjugated antisense oligonucleotide and Angiotensinogen synthesis inhibitor. Tonlamarsen specifically reduces the production of Angiotensinogen in the liver and plasma, and exhibits extremely low activity in the kidneys. Tonlamarsen can be used in research related to hypertension and heart failure.
For research use only. We do not sell to patients.
- CAS No.: 2589926-20-3
- Formula: C241H349N65O12P16S12
- Molecular Weight:7021.13
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Angiotensin Receptor Isoforms
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Biological Activity
Angiotensinogen[1]
Tonlamarsen significantly reduces plasma AGT levels in subjects, while showing no signals of hyperkalemia, renal dysfunction, hypotension, liver dysfunction or thrombocytopenia (off-target effects)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2589926-20-3
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Molecular Weight 7021.13
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Formula C241H349N65O12P16S12
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SMILES
[Tonlamarsen]
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Synonyms
ION-904
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Sequence
DNA, d([2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rG-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]m5C-T-sp-G-sp-A-sp-T-sp-T-sp-T-sp-G-sp-T-sp-m5C-sp-m5C-sp-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-(3′→4′)-[2′,5′-anhydro-6′-deoxy-4′-C-(hydroxymethyl)-α-L-mannofurano]G-sp-[2′-O-(2-methoxyethyl)]rG), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)