Agtr1a - angiotensin II receptor, type 1a Gene

Also Known as AT1; AT1A; AT1R; Agtr1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24180

Summary

Enables D1 Dopamine Receptor binding activity; angiotensin type I receptor activity; and protein kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cation homeostasis; and response to glucocorticoid. Located in several cellular components, including basolateral plasma membrane; organelle outer membrane; and recycling endosome. Used to study several diseases, including asthma; chronic kidney disease; congestive heart failure; hypertension (multiple); and nephritis. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); glomerulosclerosis (multiple); hyperinsulinism; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Agtr1a Products (2)

mRNA Protein Name
NM_030985.4 NP_112247.2 type-1 angiotensin II receptor A
NM_030985.4 NP_112247.2 type-1 angiotensin II receptor A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D1 dopamine receptor binding IPI
IPI: Inferred from physical interaction
22193384 RGD
enables angiotensin type I receptor activity IDA
IDA: Inferred from direct assay
2041570 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14559250 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
9287353 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9092554 RGD
involved in activation of Janus kinase activity IMP
IMP: Inferred from mutant phenotype
9314843 RGD
involved in angiotensin-activated signaling pathway IMP
IMP: Inferred from mutant phenotype
21769867 RGD
involved in cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
17537984 RGD
involved in dopamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
20097214 RGD
involved in drinking behavior IMP
IMP: Inferred from mutant phenotype
9622148 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11906170 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
32324784 RGD
involved in positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
20702798 RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
17537984 RGD
involved in positive regulation of calcium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
15569855 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
22645419 RGD
involved in positive regulation of receptor recycling IDA
IDA: Inferred from direct assay
14559250 RGD
involved in positive regulation of superoxide anion generation IMP
IMP: Inferred from mutant phenotype
21076237 RGD
involved in regulation of pH IDA
IDA: Inferred from direct assay
11906170 RGD
involved in renin-angiotensin regulation of aldosterone production IMP
IMP: Inferred from mutant phenotype
21318332 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
18252761 RGD
involved in response to angiotensin IEP
IEP: Inferred from expression pattern
8986922 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
7594440 RGD
involved in response to estrogen IDA
IDA: Inferred from direct assay
12810582 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
15544836 RGD
involved in response to salt stress IEP
IEP: Inferred from expression pattern
9095078 RGD
involved in vasoconstriction IMP
IMP: Inferred from mutant phenotype
20955746 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
14559250 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
12110004 RGD
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
14559250 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15590154 RGD
located in organelle outer membrane IDA
IDA: Inferred from direct assay
15590154 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
14559250 RGD
located in recycling endosome IDA
IDA: Inferred from direct assay
14559250 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

type-1 angiotensin II receptor A

type-1A angiotensin II receptor

  • AT1 receptor A

  • angiotensin II type-1 receptor A

  • angiotensin II type-1A receptor

  • angiotensin receptor 1a

  • vascular type-1 angiotensin II receptor

Agtr1a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Agtr1 P25095 AGT Homo sapiens P01019
Saturation Binding
18202720
Cross: Cross-species interaction Intra: Intraspecies interaction