SNX12 - sorting nexin 12 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29934

About SNX12

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,059,247-71,073,426 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues and 15 paralogues. Ubiquitous expression in kidney (RPKM 19.5), thyroid (RPKM 17.8) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

SNX12 Products (5)

mRNA Protein Name
NM_001256185.2 NP_001243114.1 sorting nexin-12 isoform 1
NM_001256186.2 NP_001243115.1 sorting nexin-12 isoform 2
NM_001256187.2 NP_001243116.1 sorting nexin-12 isoform 3
NM_001256188.2 NP_001243117.1 sorting nexin-12 isoform 4
NM_013346.4 NP_037478.2 sorting nexin-12 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
22709416 GOA
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
22719997 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of early endosome to late endosome transport IDA
IDA: Inferred from direct assay
22719997 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22709416 GOA
involved in negative regulation of protein catabolic process IDA
IDA: Inferred from direct assay
22719997 GOA
involved in negative regulation of protein processing IDA
IDA: Inferred from direct assay
22709416 GOA
involved in negative regulation of protein transport IDA
IDA: Inferred from direct assay
22719997 GOA
involved in regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
22709416 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
22709416 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX12 Protein Structure

PX

PX: PX domain (28 - 148)

  • 0
  • 100
  • 162 a.a.
Protein Preferred Names Protein Names

sorting nexin-12

SNX12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SNX12 Q9UMY4 KLKB1 Homo sapiens P03952
Y2H Array
32814053
Intra
SNX12 Q9UMY4 KLKB1 Homo sapiens P03952
Validated Y2H
32814053
Intra
SNX12 Q9UMY4 KLKB1 Homo sapiens P03952
Y2H Pooling
32814053
Intra
SNX12 Q9UMY4 CCT2 Homo sapiens P78371
Validated Y2H
32814053
Intra
SNX12 Q9UMY4 CCT2 Homo sapiens P78371
Y2H Array
32814053
Intra
SNX12 Q9UMY4 CCT2 Homo sapiens P78371
Y2H Pooling
32814053
Intra
SNX12 Q9UMY4 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
SNX12 Q9UMY4 ARL6IP1 Homo sapiens Q15041
Y2H Array
25416956
Intra
SNX12 Q9UMY4 LPL Homo sapiens P06858
Y2H Array
32814053
Intra
SNX12 Q9UMY4 LPL Homo sapiens P06858
Validated Y2H
32814053
Intra
SNX12 Q9UMY4 LPL Homo sapiens P06858
Y2H Pooling
32814053
Intra
SNX12 Q9UMY4 PACSIN1 Homo sapiens Q9BY11
Validated Y2H
32814053
Intra
SNX12 Q9UMY4 PACSIN1 Homo sapiens Q9BY11
Y2H Array
32814053
Intra
SNX12 Q9UMY4 PACSIN1 Homo sapiens Q9BY11
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169557 CDKI-IN-1 Inhibitor / Unkown
HY-RS13525 SNX12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SNX12 RGD RGD:1565585
Felis catus SNX12 VGNC VGNC:65543
Bos taurus SNX12 VGNC VGNC:35093
Mus musculus SNX12 MGD MGI:1919331
Macaca mulatta SNX12 VGNC VGNC:77707
Others SNX12 NCBI