2. Epigenetics Immunology/Inflammation
  3. Small Interfering RNA (siRNA) Asialoglycoprotein Receptor (ASGPR)
  4. Zilebesiran sodium

Zilebesiran sodium  (Synonyms: AD-85481 sodium; ALN-AGT sodium)

Cat. No.: HY-145649A
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Zilebesiran (AD-85481; ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. Zilebesiran sodium binds to the hepatic asialoglycoprotein receptor (ASGPR), activates the RNA-induced silencing complex to degrade hepatic angiotensinogen mRNA, thereby inhibiting the gene expression and synthesis of angiotensinogen. Zilebesiran sodium dose-dependently reduces serum angiotensinogen levels and 24-hour ambulatory blood pressure, with its effect persisting throughout the circadian cycle. Zilebesiran sodium is applicable to research related to hypertension.

For research use only. We do not sell to patients.

RNA, (Gm-sp-Um-sp-Cm-Am-Um-Cm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)A-Um-Gm-Am-Gm-Am-Gm-Um-Am-Cm-Am), 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] sodium salt, complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)G-sp-Um-Am-Cm-(3'→3')-[1-de-β-D-ribofuranosyl-1-[(2S)-2,3-dihydroxypropyl]]m5U-(2'→5')-Cm-Um-Cm-Am-Um-Um-Gm-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)G-Am-Um-Gm-Am-Cm-sp-Gm-sp-Am) sodium salt (1:21:1:22)

Zilebesiran sodium Chemical Structure

CAS No. : 2380166-34-5

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Zilebesiran sodium Related Antibodies

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Description

Zilebesiran (AD-85481; ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. Zilebesiran sodium binds to the hepatic asialoglycoprotein receptor (ASGPR), activates the RNA-induced silencing complex to degrade hepatic angiotensinogen mRNA, thereby inhibiting the gene expression and synthesis of angiotensinogen. Zilebesiran sodium dose-dependently reduces serum angiotensinogen levels and 24-hour ambulatory blood pressure, with its effect persisting throughout the circadian cycle. Zilebesiran sodium is applicable to research related to hypertension[1][2].

In Vivo

AGT siRNA (analog of Zilebesiran) (10 mg/kg; s.c.; once every 2 weeks for a total of 4 weeks) sodium exerts significant hypotensive effects in spontaneously hypertensive rats, 5/6 nephrectomized chronic kidney disease rats, and streptozotocin (STZ) (HY-13753)-induced diabetic rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

16389 (free acid)

Formula

C532H678F7N177Na43O321P43S6
CAS No.
SMILES

[Zilebesiran (sodium)]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Zilebesiran sodium Related Classifications

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Keywords:

Zilebesiran2380166-34-5AD-85481ALN-AGTAD85481AD 85481Small Interfering RNA (siRNA)Asialoglycoprotein Receptor (ASGPR)Asialoglycoprotein ReceptorAshwell-Morell ReceptorInhibitorinhibitorinhibit

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