ODN 24888
ODN 24888 is an guanine-modified inhibitory oligonucleotides (INH-ODN), shows potent inhibition on TLR7/TLR9-mediated signaling. ODN 24888 impairs IFN-α level and NF-κB activation, inhibits IL-6 release. ODN 24888 involves in immune and inflammatory responses, can be used as a vaccine adjuvant.
The free form of the compound is prone to instability, it is advisable to consider the stable salt form (ODN 24888 sodium) that retains the same biological activity.
For research use only. We do not sell to patients.
- CAS No.: 1964506-30-6
- Molecular Weight:4904.00
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
Description
IC50 & Target
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TLR7 |
TLR9 |
Chemical Information
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CAS No. 1964506-30-6
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Appearance Solid
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Molecular Weight 4904.00
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Color White to off-white
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SMILES
[DNA, d(P-thio)(T-C-C-T-G-G-C-c7rGm-G-G-G-A-A-G-T)]
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Sequence
DNA, d(P-thio)(T-C-C-T-G-G-C-c7rGm-G-G-G-A-A-G-T)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2242 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)