1964506-30-6
1964506-30-6
Chemical Structure
ODN 24888
- CAS No.: 1964506-30-6
- Formula:N/A
- Molecular Weight:4904.00
SMILES: [DNA, d(P-thio)(T-C-C-T-G-G-C-c7rGm-G-G-G-A-A-G-T)]
Biological Activity: ODN 24888 is an guanine-modified inhibitory oligonucleotides (INH-ODN), shows potent inhibition on TLR7/TLR9-mediated signaling. ODN 24888 impairs IFN-α level and NF-κB activation, inhibits IL-6 release. ODN 24888 involves in immune and inflammatory responses, can be used as a vaccine adjuvant[1][2].
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ODN 24888 | ODN 24888 is an guanine-modified inhibitory oligonucleotides (INH-ODN), shows potent inhibition on TLR7/TLR9-mediated signaling. ODN 24888 impairs IFN-α level and NF-κB activation, inhibits IL-6 release. ODN 24888 involves in immune and inflammatory responses, can be used as a vaccine adjuvant. | |||||||||||||||||||||
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References
- [1]. Saul Meike, et al. Reduction of bone resorption, especially in chronic joint diseases: Germany, DE102019122014 A1. 2021-02-18.
- [2]. Römmler F, et al. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated im mune responses of human immune cells. PLoS One. 2015 Feb 19;10(2):e0116703. [Content Brief]
