2. Metabolic Enzyme/Protease Anti-infection
  3. Apolipoprotein HCV
  4. Mipomersen sodium

Mipomersen sodium  (Synonyms: ISIS 301012)

Cat. No.: HY-108764 Purity: 95.60%
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Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH).

For research use only. We do not sell to patients.

CAS No. : 629167-92-6

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Based on 2 publication(s) in Google Scholar

Other Forms of Mipomersen sodium:

Mipomersen sodium Related Antibodies

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
ELISA
Cell Imaging/Staining
WB

    Mipomersen sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137.  [Abstract]

    Effects of Lomitapide and Mipomersen on granulosa and theca cell viability under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 h (3H) and allowed recovery for 13 hr (3H13R). Cells collected at indicated time points were used for viability analysis. *; significant effect by HS (vs. NC within the same pharmacological treatment at the same time point), #; significant effect by time (vs. 3H within the same thermal and pharmacological treatment), +; significant effect by Lom+Mip (vs. vehicle of the same thermal treatment at the same time), P < 0.05, n = 3.

    Mipomersen sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137.  [Abstract]

    Effects of Lomitapide and Mipomersen on granulosa and theca cell viability under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 8 hr (8H) and allowed recovery for 8 hr (8H8R). Cells collected at indicated time points were used for viability analysis. *; significant effect by HS (vs. NC within the same pharmacological treatment at the same time point), #; significant effect by time (vs. 8H within the same thermal and pharmacological treatment), +; significant effect by Lom+Mip (vs. vehicle of the same thermal treatment at the same time), P < 0.05, n = 3.

    Mipomersen sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137.  [Abstract]

    Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (MTTP and ApoB inhibitor, respectively, 2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 hr (3H) and allowed recovery at 37°C for 13 hr (3H13R). Cells maintained at 37°C served as a neutral control (16H NC). Medium were collected for VLDL isolation and then used for VLDL-apoB determination through the ELISA method.

    Mipomersen sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137.  [Abstract]

    Effects of Lomitapide and Mipomersen on neutral lipid and cholesterol content of granulosa and theca cells under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 (3H) and allowed recovery for 13 (3H13R). Cells collected at indicated time points were used for neutral lipid staining by BODIPYTM493/503 and for cholesterol content determination using commercial kits.

    Mipomersen sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137.  [Abstract]

    Effects of Lomitapide and Mipomersen on cell proliferation and inflammatory response of granulosa and theca cells under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 hr (3H) and allowed recovery for 13 (3H13R). Cells collected at indicated time points were used for PCNA (proliferating cell nuclear antigen) and IL-1β (interleukin-1β) expression through Western blot analysis. Results were normalized to β-actin and expressed as ratios relative to the control (NC 16H or NC 8H).

    View All Apolipoprotein Isoform Specific Products:

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    apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

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    Description

    Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH)[1][2].

    IC50 & Target

    apoB

     

    In Vitro

    Mipomersen predominantly distributes to the liver and decreases the production of apoB-100, the primary structural protein of the atherogenic lipoproteins including low density lipoprotein (LDL), thereby reducing plasma LDL-cholesterol and apoB-100 concentrations[2].
    Apolipoprotein (apo) B, a large amphipathic protein, plays a fundamental role in human lipoprotein metabolism. ApoB-100 is also a ligand for LDL receptor-mediated endocytosis of LDL by cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Mipomersen sodium Related Antibodies
    Clinical Trial
    Molecular Weight

    7179.15 (free acid)

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    DNA, d(P-thio)([2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-A-G-T-m5C-T-G-m5C-T-T-m5C-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC), sodium salt (1:19)
    SMILES

    [Mipomersen (sodium)]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, stored under nitrogen, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (Need ultrasonic)

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL; Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
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    Mipomersen sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Mipomersen629167-92-6ISIS 301012ISIS301012ISIS-301012ApolipoproteinHCVHepatitis C virusApoB-100LDLendocytosisASOhomozygousfamilialhypercholesterolaemiaHoFHRNase-HHeFHatherosclerosisInhibitorinhibitorinhibit

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