Mipomersen (Synonyms: ISIS 301012 free base)

Name: Mipomersen
Brand: MedChemExpress
SKU: HY-148647
Rating: 5.0 (2 reviews)

Cat. No.: HY-148647 Purity: 96.88%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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Mipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH).

For research use only. We do not sell to patients.

DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rC-A-G-T-m5C-T-G-m5C-T-T-m5C-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rC)

CAS No. : 1000120-98-8

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Mipomersen:

Mipomersen sodium In-stock

2 Publications Citing Use of MCE Mipomersen

Cell Proliferation/Viability Assay

ELISA

Cell Imaging/Staining

: Mipomersen purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]; Effects of Lomitapide and Mipomersen on granulosa and theca cell viability under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 h (3H) and allowed recovery for 13 hr (3H13R). Cells collected at indicated time points were used for viability analysis. *; significant effect by HS (vs. NC within the same pharmacological treatment at the same time point), #; significant effect by time (vs. 3H within the same thermal and pharmacological treatment), +; significant effect by Lom+Mip (vs. vehicle of the same thermal treatment at the same time), P < 0.05, n = 3.

: Mipomersen purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]; Effects of Lomitapide and Mipomersen on granulosa and theca cell viability under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 8 hr (8H) and allowed recovery for 8 hr (8H8R). Cells collected at indicated time points were used for viability analysis. *; significant effect by HS (vs. NC within the same pharmacological treatment at the same time point), #; significant effect by time (vs. 8H within the same thermal and pharmacological treatment), +; significant effect by Lom+Mip (vs. vehicle of the same thermal treatment at the same time), P < 0.05, n = 3.

: Mipomersen purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]; Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (MTTP and ApoB inhibitor, respectively, 2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 hr (3H) and allowed recovery at 37°C for 13 hr (3H13R). Cells maintained at 37°C served as a neutral control (16H NC). Medium were collected for VLDL isolation and then used for VLDL-apoB determination through the ELISA method.

: Mipomersen purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]; Effects of Lomitapide and Mipomersen on neutral lipid and cholesterol content of granulosa and theca cells under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 (3H) and allowed recovery for 13 (3H13R). Cells collected at indicated time points were used for neutral lipid staining by BODIPYTM493/503 and for cholesterol content determination using commercial kits.

: Mipomersen purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]; Effects of Lomitapide and Mipomersen on cell proliferation and inflammatory response of granulosa and theca cells under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 hr (3H) and allowed recovery for 13 (3H13R). Cells collected at indicated time points were used for PCNA (proliferating cell nuclear antigen) and IL-1β (interleukin-1β) expression through Western blot analysis. Results were normalized to β-actin and expressed as ratios relative to the control (NC 16H or NC 8H).

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View All Apolipoprotein Isoform Specific Products:

View All Isoforms

apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

apoB

In Vitro

Mipomersen (800 and 1000 μg/mL; 72 hours) reduces 80%-85% intracellular HCV RNA in Huh7/CD81 WT cells with HCVcc (JFH1) infection^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mipomersen (25 mg/kg; i.p., twice weekly for 11 weeks) affects levels of h-apoB, h-apoB-100, Lp(a) and OxPL/h-apoB^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Transgenic mice overexpressing human apolipoprotein B-100 (h-apoB mice) or h-apoB-100 plus human apo(a) (Lp(a) mice)^[1]
Dosage:	25 mg/kg
Administration:	Intraperitoneal injection; 25 mg/kg, twice weekly for 11 weeks
Result:	Time-dependently reduced the level of h-apoB-100 in Lp(a) mice and h-apoB in h-apoB mice.

Molecular Weight

7179.15

CAS No.

1000120-98-8

Appearance

Solid

Color

White to off-white

SMILES

[Mipomersen]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (13.93 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.1393 mL	0.6965 mL	1.3929 mL
5 mM	0.0279 mL	0.1393 mL	0.2786 mL
10 mM	0.0139 mL	0.0696 mL	0.1393 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 96.88%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (246 KB)

Handling Instructions (2242 KB)

References

[1]. Merki E, et al. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 2008 Aug 12;118(7):743-53. [Content Brief]

[2]. Schaefer EA, et al. Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C. World J Gastroenterol. 2016 Dec 7;22(45):9954-9965. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.1393 mL	0.6965 mL	1.3929 mL	3.4823 mL
	5 mM	0.0279 mL	0.1393 mL	0.2786 mL	0.6965 mL
	10 mM	0.0139 mL	0.0696 mL	0.1393 mL	0.3482 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Mipomersen Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mipomersen1000120-98-8ISIS 301012ISIS301012ISIS-301012ApolipoproteinHCVHepatitis C virusantisense oligonucleotideHoFHHuh7/CD81JFH1Inhibitorinhibitorinhibit

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Mipomersen (Synonyms: ISIS 301012 free base)

Customer Review

Other Forms of Mipomersen:

Mipomersen Related Antibodies

2 Publications Citing Use of MCE Mipomersen

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Apolipoprotein Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Mipomersen Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Mipomersen Related Classifications

Keywords:

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Customer Review

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