SLC6A15 - solute carrier family 6 member 15 Gene

Also Known as V7-3; NTT73; SBAT1; hv7-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55117

About SLC6A15

Cytogenetic location: 12q21.31 Genomic coordinates (GRCh38): 12:84,859,491-84,912,799 (from NCBI)

This gene has 45 transcripts (splice variants), 219 orthologues and 19 paralogues. Biased expression in brain (RPKM 5.0), placenta (RPKM 1.2) and 3 other tissues.

Summary

This gene encodes a member of the solute carrier family 6 protein family which transports neutral Amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

SLC6A15 Products (3)

mRNA Protein Name
NM_001146335.3 NP_001139807.1 sodium-dependent neutral amino acid transporter B(0)AT2 isoform 3
NM_018057.7 NP_060527.2 sodium-dependent neutral amino acid transporter B(0)AT2 isoform 2
NM_182767.6 NP_877499.1 sodium-dependent neutral amino acid transporter B(0)AT2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables branched-chain amino acid:sodium symporter activity IDA
IDA: Inferred from direct assay
16226721 GOA
enables neutral L-amino acid:sodium symporter activity IDA
IDA: Inferred from direct assay
16226721 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in neutral amino acid transport IDA
IDA: Inferred from direct assay
16226721 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
16226721 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC6A15 Protein Structure

SNF

SNF: Sodium:neurotransmitter symporter family (61 - 643)

  • 0
  • 200
  • 400
  • 600
  • 730 a.a.
Protein Preferred Names Protein Names

sodium-dependent neutral amino acid transporter B(0)AT2

  • homolog of rat orphan transporter v7-3

SLC6A15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC6A15 Q9H2J7 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
SLC6A15 Q9H2J7 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 3

  • Epileptic Encephalopathy, Early Infantile, 3

  • DEE3

  • Eiee3

  • Early Myoclonic Encephalopathy

  • Developmental And Epileptic Encephalopathy, 3

  • Early Infantile Epileptic Encephalopathy 3

  • Eme

  • Neonatal Epilepsy With Suppression-Burst Pattern

  • Encephalopathy, Epileptic, Early Infantile, Type 3
Hartnup Disorder

  • Hartnup Disease

  • HND

  • Neutral 1 Amino Acid Transport Defect

  • Neutral Amino Acid Transport Defect

  • Deficiency Of Tryptophan Oxygenase

  • Hartnup'S Disease

  • Aminoaciduria, Hartnup Type

  • Disorder Of Neutral Amino Acid Transport
Retinitis Pigmentosa 68

  • RP68

  • Retinitis Pigmentosa, Type 68
Iminoglycinuria

  • Iminoglycinuria, Digenic

  • IG
Hyperekplexia

  • Hereditary Hyperekplexia

  • Kok Disease

  • Congenital Stiff Man Syndrome

  • Familial Startle Disease

  • Sthe

  • Stiff-Baby Syndrome

  • Hereditary Hyperexplexia

  • Startle Disease

  • Exaggerated Startle Reaction

  • Hyperexplexia Hereditary

  • Startle Disease, Familial

  • Startle Reaction, Exaggerated

  • Stiff-Man Syndrome, Congenital

  • Stiff-Person Syndrome, Congenital

  • Congenital Stiff-Man Syndrome

  • Congenital Stiff-Person Syndrome

  • Familial Hyperekplexia

  • Startle Syndrome

  • Stiff Baby Syndrome

  • Hyperekplexia, Hereditary

  • Stiff-Person Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13301 SLC6A15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC6A15 RGD RGD:628664
Mus musculus SLC6A15 MGD MGI:2143484
Felis catus SLC6A15 VGNC VGNC:65411
Canis familiaris SLC6A15 VGNC VGNC:46458
Bos taurus SLC6A15 VGNC VGNC:34918
Macaca mulatta SLC6A15 VGNC VGNC:77691
Others SLC6A15 NCBI