SUN2 - Sad1 and UNC84 domain containing 2 Gene

Also Known as UNC84B; rab5IP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25777

About SUN2

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,734,734-38,755,998 (from NCBI)

This gene has 19 transcripts (splice variants), 217 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 47.2), bone marrow (RPKM 33.2) and 25 other tissues.

Summary

SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the Cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]

SUN2 Products (22)

mRNA	Protein	Name
NM_001199579.2	NP_001186508.1	SUN domain-containing protein 2 isoform 1
NM_001199580.2	NP_001186509.1	SUN domain-containing protein 2 isoform 2
NM_001394427.1	NP_001381356.1	SUN domain-containing protein 2 isoform 3
NM_001394428.1	NP_001381357.1	SUN domain-containing protein 2 isoform 1
NM_001394429.1	NP_001381358.1	SUN domain-containing protein 2 isoform 4
NM_001394430.1	NP_001381359.1	SUN domain-containing protein 2 isoform 4
NM_001394431.1	NP_001381360.1	SUN domain-containing protein 2 isoform 5
NM_001394432.1	NP_001381361.1	SUN domain-containing protein 2 isoform 2
NM_001394433.1	NP_001381362.1	SUN domain-containing protein 2 isoform 2
NM_001394434.1	NP_001381363.1	SUN domain-containing protein 2 isoform 2
NM_001394435.1	NP_001381364.1	SUN domain-containing protein 2 isoform 2
NM_001394436.1	NP_001381365.1	SUN domain-containing protein 2 isoform 6
NM_001394437.1	NP_001381366.1	SUN domain-containing protein 2 isoform 6
NM_001394438.1	NP_001381367.1	SUN domain-containing protein 2 isoform 7
NM_001394439.1	NP_001381368.1	SUN domain-containing protein 2 isoform 8
NM_001394440.1	NP_001381369.1	SUN domain-containing protein 2 isoform 8
NM_001394441.1	NP_001381370.1	SUN domain-containing protein 2 isoform 8
NM_001394442.1	NP_001381371.1	SUN domain-containing protein 2 isoform 9
NM_001394443.1	NP_001381372.1	SUN domain-containing protein 2 isoform 10
NM_001394444.1	NP_001381373.1	SUN domain-containing protein 2 isoform 11
NM_001394445.1	NP_001381374.1	SUN domain-containing protein 2 isoform 11
NM_015374.3	NP_056189.1	SUN domain-containing protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytoskeleton-nuclear membrane anchor activity	IDA IDA: Inferred from direct assay	18396275	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22632968	GOA
enables lamin binding	IDA IDA: Inferred from direct assay	19933576	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18396275	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nuclear matrix anchoring at nuclear membrane	IDA IDA: Inferred from direct assay	19933576	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of meiotic nuclear membrane microtubule tethering complex	IDA IDA: Inferred from direct assay	18396275	GOA
colocalizes with nuclear envelope	IDA IDA: Inferred from direct assay	21610090	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	16380439	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUN2 Protein Structure

Sad1_UNC

0
200
400
600
717 a.a.

Protein Preferred Names	Protein Names
SUN domain-containing protein 2	Sad1 unc-84 domain protein 2

SUN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SUN2	Q9UH99	NRM	Homo sapiens	Q8IXM6	Y2H Prey Pooling	25416956
Intra	SUN2	Q9UH99	RAB5A	Homo sapiens	P20339	Anti Tag CoIP	33961781
Intra	SUN2	Q9UH99	RAB5A	Homo sapiens	P20339	Anti Tag CoIP	28514442
Intra	SUN2	Q9UH99	SYNE1	Homo sapiens	Q8NF91	Pull Down	22632968
Intra	SUN2	Q9UH99	SYNE2	Homo sapiens	Q8WXH0	GMS	33058875
Intra	SUN2	Q9UH99	SYNE2	Homo sapiens	Q8WXH0	Pull Down	22555292
Intra	SUN2	Q9UH99	SYNE1	Homo sapiens	Q8NF91	GMS	33058875
Intra	SUN2	Q9UH99	SYNE2	Homo sapiens	Q8WXH0	Pull Down	30833792
Intra	SUN2	Q9UH99	SYNE1	Homo sapiens	Q8NF91	GMS	33393904
Intra	SUN2	Q9UH99	RAB5A	Homo sapiens	P20339	Y2H	21988832
Intra	SUN2	Q9UH99	SYNE3	Homo sapiens	Q6ZMZ3	X-Ray Diffraction	33058875
Intra	SUN2	Q9UH99	SYNE3	Homo sapiens	Q6ZMZ3	GMS	33058875
Cross	SUN2	Q9UH99	ap3a_sars2	SARS-CoV-2	P0DTC3	Y2H Array	36217030
Intra	SUN2	Q9UH99	KPNA2	Homo sapiens	P52292	Pull Down	20551905
Intra	SUN2	Q9UH99	LMNA	Homo sapiens	P02545	Pull Down	22555292
Intra	SUN2	Q9UH99	LMNA	Homo sapiens	P02545	Anti Tag CoIP	33961781
Intra	SUN2	Q9UH99	COPB1	Homo sapiens	P53618	Pull Down	22555292
Intra	SUN2	Q9UH99	COPB1	Homo sapiens	P53618	Pull Down	20551905
Intra	SUN2	Q9UH99	EMD	Homo sapiens	P50402	Pull Down	30833792
Intra	SUN2	Q9UH99	EMD	Homo sapiens	P50402	Pull Down	19933576
Intra	SUN2	Q9UH99	SYNE4	Homo sapiens	Q8N205	GMS	33393904
Intra	SUN2	Q9UH99	SYNE4	Homo sapiens	Q8N205	X-Ray Diffraction	33058875
Intra	SUN2	Q9UH99	SYNE4	Homo sapiens	Q8N205	GMS	33058875
Intra	SUN2	Q9UH99	KASH5	Homo sapiens	Q8N6L0	GMS	33058875
Intra	SUN2	Q9UH99	KASH5	Homo sapiens	Q8N6L0	X-Ray Diffraction	33058875
Intra	SUN2	Q9UH99	KASH5	Homo sapiens	Q8N6L0	GMS	33393904

Cross: Cross-species interaction Intra: Intraspecies interaction

SUN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82280	SUN2 Antibody (YA2025)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P82280A	SUN2 Antibody (YA2025)(PBS only)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Emery-Dreifuss Muscular Dystrophy	Edmd Emery-Dreifuss Syndrome Muscular Dystrophy, Emery-Dreifuss Humeroperoneal Neuromuscular Disease Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures Scapuloperoneal Syndrome, X-Linked Benign Scapuloperoneal Muscular Dystrophy With Early Contractures Muscular Dystrophy, Emery-Dreifuss Type Muscular Dystrophy Emery-Dreifuss Dystrophy, Muscular, Emery-Dreifuss Emd - [Emery-Dreifuss Muscular Dystrophy]
Chronic Fatigue Syndrome	Myalgic Encephalomyelitis Postviral Fatigue Syndrome Cfs Myalgic Encephalitis Encephalomyelitis, Myalgic Chronic Fatigue Fatigue Syndrome, Chronic Benign Myalgic Encephalomyelitis Akureyri Akureyri Disease Cfs - [Chronic Fatigue Syndrome] Epidemic Neuromyasthenia Myalgic Encephalomyelitis Syndrome Me - [Myalgic Encephalomyelitis] Pvfs - [Postviral Fatigue Syndrome] Neuromyasthenia Iceland Disease Icelandic Disease
Emery-Dreifuss Muscular Dystrophy 7, Autosomal Dominant	EDMD7 Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 7 Emery-Dreifuss Muscular Dystrophy 7, Ad Emd7 Dystrophy, Muscular, Emery-Dreifuss, Type 7, Autosomal Dominant
Reynolds Syndrome	Primary Biliary Cirrhosis, Scleroderma, Raynaud Disease, And Telangiectasia Primary Biliary Cirrhosis And Systemic Scleroderma REYNS Primary Biliary Cirrhosis Scleroderma Raynaud Disease And Telangiectasia
Emery-Dreifuss Muscular Dystrophy 1, X-Linked	EDMD1 Emd1 Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures X-Linked Emery-Dreifuss Muscular Dystrophy 1 Humeroperoneal Neuromuscular Disease X-Linked Emery-Dreifuss Muscular Dystrophy Scapuloperoneal Syndrome, X-Linked, Formerly Humeroperoneal Neuromuscular Disease, Formerly Scapuloperoneal Syndrome, X-Linked Muscular Dystrophy Tardive Dreifuss-Emery Type With Contractures Scapuloperoneal Syndrome X-Linked X-Edmd Dystrophy, Muscular, Emery-Dreifuss, Type 1, X-Linked
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Emery-Dreifuss Muscular Dystrophy 5, Autosomal Dominant	EDMD5 Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 5 Emd5 Dystrophy, Muscular, Emery-Dreifuss, Type 5, Autosomal Dominant
Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant	EDMD2 Autosomal Dominant Emery-Dreifuss Muscular Dystrophy Emd2 Emery-Dreifuss Muscular Dystrophy, Autosomal Dominant Scapuloilioperoneal Atrophy With Cardiopathy Muscular Dystrophy With Early Contractures And Cardiomyopathy, Autosomal Dominant Hauptmann-Thannhauser Muscular Dystrophy Cardiomyopathy, Dilated, With Quadriceps Myopathy Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 2 Muscular Dystrophy, Limb-Girdle, Type 1b Muscular Dystrophy, Limb-Girdle, Type 1b, Formerly Lgmd1b, Formerly Muscular Dystrophy, Proximal, Type 1b, Formerly Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1b Lgmd1b Limb-Girdle Muscular Dystrophy 1b Muscular Dystrophy, Proximal, Type 1b Muscular Dystrophy With Early Contractures And Cardiomyopathy Autosomal Dominant
Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive	EDMD3 Autosomal Recessive Emery-Dreifuss Muscular Dystrophy 3 Autosomal Recessive Emery-Dreifuss Muscular Dystrophy Emery-Dreifuss Muscular Dystrophy Atypical Autosomal Recessive Dystrophy, Muscular, Emery-Dreifuss, Type 3, Autosomal Recessive Emery-Dreifuss Muscular Dystrophy 3
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Muscular Dystrophy, Congenital, Lmna-Related	Congenital Muscular Dystrophy Congenital Muscular Dystrophy Due To Lmna Mutation MDCL L-Cmd Lmna-Related Congenital Muscular Dystrophy Muscular Dystrophy, Congenital Congenital Muscular Dystrophy Lmna-Related Lmna-Related Cmd Cmd Mdc Muscular Dystrophy Congenital Lmna-Related Dystrophy, Muscular, Congenital, Lmna-Related Dystrophy, Muscular, Congenital Hereditary Muscular Dystrophy Congenital Hereditary Muscular Dystrophy Congenital Progressive Muscular Dystrophy Hereditary Progressive Muscular Dystrophy
Emery-Dreifuss Muscular Dystrophy 4, Autosomal Dominant	EDMD4 Emery-Dreifuss Muscular Dystrophy 4 With Variable Features Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 4 Emd4 Dystrophy, Muscular, Emery-Dreifuss, Type 4, Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 4
Limb-Girdle Muscular Dystrophy	Lgmd Limb Girdle Muscular Dystrophy Muscular Dystrophies, Limb-Girdle Erb'S Muscular Dystrophy Leyden-Mbius Muscular Dystrophy Limb-Girdle Syndrome Myopathic Limb-Girdle Syndrome Limb Girdle Muscular Dystrophy Limb-Girdle Dystrophy, Muscular, Limb-Girdle Lgmd - [Limb-Girdle Muscular Dystrophy] Limb Girdle Muscle Dystrophy Limb-Girdle Myopathy
Myopathy, X-Linked, With Postural Muscle Atrophy	Emery-Dreifuss Muscular Dystrophy 6, X-Linked XMPMA X-Linked Myopathy With Postural Muscle Atrophy X-Linked Emery-Dreifuss Muscular Dystrophy 6 EDMD6 Emd6
Charcot-Marie-Tooth Disease, Axonal, Type 2b1	Charcot-Marie-Tooth Disease Type 2b1 Charcot-Marie-Tooth Disease, Type 2b1 CMT2B1 Autosomal Recessive Axonal Cmt4c1 Autosomal Recessive Charcot-Marie-Tooth Disease Type 2b1 Charcot-Marie-Tooth Disease Neuronal Type 2b1 Charcot-Marie-Tooth Neuropathy Type 2b1 Charcot-Marie-Tooth Disease, Neuronal, Type 2b1 Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b1 Charcot-Marie-Tooth Neuropathy, Type 2b1 Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b1 Ar-Cmt2b1 Charcot-Marie-Tooth Disease 2b1 Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B1 Charcot-Marie-Tooth Disease Axonal Type 2b1
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Greenberg Dysplasia	Hem Dysplasia Greenberg Skeletal Dysplasia Hem Skeletal Dysplasia GRBGD Hydrops-Ectopic Calcification-Moth-Eaten Skeletal Dysplasia Moth-Eaten Skeletal Dysplasia Chondrodystrophy, Hydropic And Prenatally Lethal Type Hydrops-Ectopic Calcification-Motheaten Syndrome Skeletal Dysplasia, Greenberg Type Autosomal Recessive Lethal Chondrodystrophy With Congenital Hydrops Hydrops, Ectopic Calcification, Moth-Eaten Skeletal Dysplasia Hem Hem/Greenberg Dysplasia Hydrops - Ectopic Calcification - Moth-Eaten Skeletal Dysplasia
Pelger-Huet Anomaly	PHA Pelger-Huët Anomaly Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities Pelger Huet Anomaly Pelger-Huet Nuclear Anomaly
Cardiomyopathy, Dilated, 1h	Dilated Cardiomyopathy 1h Dilated Cardiomyopathy With Conduction Defect CMD1H Cardiomyopathy, Dilated, With Conduction Defect
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Myopathy	Muscular Diseases Myopathies
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14030	SUN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SUN2	VGNC	VGNC:65842
Canis familiaris	SUN2	VGNC	VGNC:46985
Bos taurus	SUN2	VGNC	VGNC:35474
Macaca mulatta	SUN2	VGNC	VGNC:78113
Mus musculus	SUN2	MGD	MGI:2443011
Rattus norvegicus	SUN2	RGD	RGD:1563141
Others	SUN2	NCBI